Development of the new transctaneous occlusion system for patent ductus arteriosus

1.动脉导管未闭三维模型的建立利用30例合并动脉导管未闭的心脏术后标本，用含钡硅橡胶制作动脉导管三维模型。最后制作三种典型的动脉导管，即最小直径为2、3、3mm的动脉导管。使用这些铸型，进行了以下研究。研究了新型导管闭塞系统的金属材料选择。并制作了不同形状的线圈。根据不同不锈钢丝直径和不同线圈圈数对线圈的变形、耐久性和柔韧性进行了评价。最后，以0.038英寸线材制作的线圈为例，获得了适当的耐久度和柔韧性。此外，我们发现，当动脉导管最小直径大于3.0mm时，同时双线圈技术是非常有效的。因此，我们为这种双线圈或三线圈技术开发了一种4 Fr端孔多用途导管。动脉导管未闭线圈闭塞后闭塞机制的评价。在动脉导管未闭闭合后6个月至1年，行血管内回声检查。使用这种技术，可以很好地定义植入物周围的内皮化。这些发现表明，线圈闭塞的长期预后将是良好的结果。

1.Establishment of three dimensional model of patent ductus arteriosusUsing 30 post mortarn cardiac specimens, which complicated with patent ductus arteriosus, anatomical model of ductus was made by barium contented silicone rubber. Finally, three types of typical ductus arteriosus were made, such as 2,3 and 3 mm of minimum diameter of ductus. Using these casts, following studies were performed.Development of a new system for ductus occlusionSelection of metal materials for the new system were studied. and formation of different shapes of coils were manufactured. Deformation, endurance and flexibility of coils were evaluated in terms of different diameter of stainless wires, and different number of coil loops. Finally, appropriate endurance and flexibility of coils were obtained in case of the coils ware made by 0.038 inch wire. Additionally, we found that simultaneous double coil technique is very effective when the minimum diameter of ductus arteriosus was more than 3.0mm. Thus, we developed a 4 Fr end-hole multipurpose catheter for this double or triple coil technique.Evaluation of occlusion mechanisms after coil occlusion of patent ductus arteriosus. At6 months to 1 years after the catheter closure of patent ductus arteriosus, intravascular echo studies were performed. Using this technique, endotherializaion around the implanted could be defined well. Such findings revealed that the long-term outcome of coil occlusion of this disease would be good outcome.