Development of alveolar ridge awgmentation with active GBR

我们计划用重组人BMP-2引导骨再生（GBR）修复牙槽骨缺损。我们将这种方法命名为<active GBR>，我们已经报告了我们的研究结果。采用该方法既可以修复牙周区较大的骨缺损，也可以修复牙周区较小的骨缺损，并且在牙槽嵴增大的动物实验中也有许多成功的结果。此外，我们不仅要用这种方法恢复下颌骨的形状，而且要恢复其功能。因此，我们将种植体植入新形成的骨中，并尝试评估rhBMP-2在下颌功能重建中的效果。首先，我们使用rhBMP-2和载体材料修复了小猎犬的下颌骨缺损。术后8周，将钛牙种植体植入新生骨中，对种植后再生骨组织进行影像学和组织学检查。结果显示，种植体与诱导骨在4周内紧密接触，新生诱导骨与种植体表面的骨结合面积随时间的增加而增加。此外，我们可以在适当的条件下放置假体上部结构和负载。因此，通过rhBMP-2- <活性GBR>，我们可以有效地修复牙槽骨缺损，实现功能康复。

We planned Guided Bone Regeneration (GBR) with recombinant human BMP-2 for the purpose of the restoration of alveolar bone defect. We named this method, <active GBR> and we already reported the results of our research.If we use this method, we can certainly restore the larger bone defects as well as the small bone defects in periodontal field and we also have many successful results of animal experiment about the alveolar ridge augmentation. Furthermore, we should restore not only the shape but the function of the mandibular bone with this method.So we inserted the dental implants in the newly formed bone and tried to evaluate the efficacy of rhBMP-2 for mandibular functional reconstructionAt first we restored the mandibular bone defects of beagle dog with rhBMP-2 and carrier material. 8 weeks after operation, titanium dental implants were inserted in the newly formed bone and we examined the regenerated bone tissue radiographically and histologically after implantation.As the results, intimate contact between the dental implants and the induced bone was observed in 4 weeks, and the area of osseointegration between newly induced bone and the implant surface increased time-dependently. Furthermore we could placeprosthetic suprastructure and load under appropriate conditions.Consequently, by <active GBR> with rhBMP-2-, we can effectively restore the alveolar bone defect for functional rehabilitation.