PromptFLASH: Real-time In-vivo FLASH dosimetry for ion beams with Prompt Gamma X-ray Spectroscopy

闪光放射治疗在保持与正常组织相似的抗肿瘤疗效的同时，表现出与正常组织显著的生物节约性，被称为闪光效应。超高剂量率或闪光率下的剂量测量是复杂的，因为剂量计在超高剂量率下可能会受到饱和的影响。目前还没有体内方法来验证所提供的闪光剂量。保证闪光过程中投放剂量的准确性是至关重要的。目前的建议集中在一种新的方法，利用辐照组织的即时伽马X射线光谱分析(PGXS)来验证体内提供的闪光剂量，该方法使用基于Gd的造影剂(GBCA)来放大伽马/X射线发射。将使用石墨量热法作为绝对剂量参考。

FLASH radiotherapy demonstrates a striking biological sparing effect of normal tissues while keeping similar anti-tumor efficacy, termed the “FLASH effect”. The measurement of dose at ultra-high-dose-rates or FLASH rates is complex as dosimeters may be susceptible to saturation at ultra-high dose rates. An in-vivo method of verifying the delivered FLASH dose is currently not available. It is vital to guarantee the accuracy of the delivered dose during FLASH. The current proposal focuses on a new method for verifying delivered FLASH dose in-vivo using prompt gamma x-ray spectroscopic (PGXS) analysis of irradiated tissue, which uses Gadolinium-Based Contrast Agents (GBCA) to amplify gamma/X-ray emission. A graphite calorimetry methodology will be used as absolute dose reference.