Research on circadian variations of biological variables, such as blood pressure, body temperature, etc.in different sleep-wake patterns.

本研究旨在探讨睡眠时相改变后，生理变量的昼夜变化。21.3yo，170.1cm，63.8kg）在受控的物理条件和生活环境下连续研究72小时。第1天睡眠时间为00：00 ~ 07：00，第2天为0，第3天为12：00 ~ 19：00，口腔温度和皮质醇在3天内保持明显的昼夜变化。血压和脉率呈明显的双相性。随着睡眠期间的低时段变化，并突然调整到新的时间表。一些血液和尿液变量显示出相位移后振幅变钝的组合变化。昼夜节律变化的调整，改变睡眠-觉醒时间表发生在不同的变量以不同的速度。主观警觉性在长时间睡眠中迅速降低，而在转移睡眠后恢复得更慢且更不有效。对相位移动的反应也取决于个人。我们将进一步分析所检查变量的节律特征，并探讨变量或变量之间的关系，考虑到个体间的差异，包括受试者的个性。

This study was aimed to investigate the changes revealed in circadian variations of biological variables, when a sleep phase was shifted.Nine male students (ave. 21.3yo, 170.1cm, 63.8kg) were studied for 72 hours continuously under a controlled physical conditions and living environment. Sleep hours were from 00 : 00 to 07 : 00 on the 1st day, zero on the 2nd day, and from 12 : 00 to 19 : 00 on the 3rd day.Oral temperature and cortisol kept significant circadian variations for 3 days. Blood pressure and pulse rate had the clear biphasic. variation with the low period during sleep, and adjusted abruptly to the new schedule. Some blood and urinary variables showed combined variations with blunted amplitudes after the phase shift. Adjustment of circadian variations to changed sleep-wake schedules occured at different rates in different variables. Subjective vigilance lowered rapidly during prolonged night, and recovered more slowly and less effectively after the shifted sleep. The reactions to the phase shift also depended on persons.We will further analyze rhythmometric characteristics of variables examined, and explore the relations between variables or symptomes, taking into account of interindividual variability including subject's personality.