Anti-neural calcium channel antibodies in amyotrophic lateral sclerosis

最近有研究表明，肌萎缩侧索硬化症(ALS)患者体内的抗电压门控钙通道(VGCC)抗体可增强钙电流，导致神经细胞死亡。尽管VGCC的al亚基有六种不同的亚型，但还没有直接表明ALS的抗体靶点是哪种神经元型的al亚基，在本研究中，我们试图利用类型特异性的抗al亚基抗体来揭示ALS血清中的抗体结合的al亚型。25%至65%的患者抗VGCC抗体呈阳性。ALS血清中VGCC抗体的异质性较强。由于不同患者抗体的类型特异性不同，这些抗体对ALS病理生理学的贡献可能因患者不同而不同。

It was recently suggested that anti-voltage-gated calcium channel (VGCC) antibody in patients with amyotrophic lateral sclerosis (ALS) could enhance Ca2+ current and cause neuronal cell death. Although more than six distinct subtypes of al subunit of VGCC have been known, it has not been shown directly which neuronal type of al subunit is the target of antibodies in ALS, In this study, using type specific anti-al subunit antibodies, we tried to reveal al subtypes, to which antibodies in ALS serum bind. Anti-VGCC antibodies are positive in 25 to 65% of patients. The heterogeneity of anti-al subumt of VGCC antibodies in ALS serum was shown. Because type-specificity for antibodies vary among patients, contributions of these antibodies to ALS pathophysiology may differ with individual patients.