Clinical diagnosis of Alzheimer's disease using quantitative EEG analysis and MRI volumetry.

尽管临床上对阿尔茨海默病(AD)的诊断方法很多，但对早期AD的诊断仍然比较困难。当几个参数同时用于这一目的时，可以得到改进。我们对19例AD患者和15例健康老年志愿者进行了脑电定量分析和MRI容积测量。与健康老年人相比，AD患者脑电的Delta、theta-1、theta-2、α-1、α-2、β-1、β-2和β-3频段的整体场强和三维磁共振全脑、左右颞叶和左右内侧颞叶的体积显著增加，而α-1、β-1和β-2频段的整体场强显著降低。阿尔茨海默病患者的全脑、左右颞叶、左右内侧颞叶以颅内间隙为标准，与健康老年人相比显著减少。在判别分析(逐步方法)中，选择左侧内侧颞叶体积、α-1全局场功率和theta-1全局场功率作为变量。通过分析，34名受试者中有32名被试被正确分类。只有两名健康的老年人被错误预测。这一连续结果的原因是对歧视使用了非常不同类型的措施。对于EEG测量，使用宽手的全局场功率作为功能参数，而对于MRI测量，使用颞叶和内侧颞叶体积作为形态测量。结论：不同检测方法的联合应用对AD的临床诊断有一定的价值。

Although many diagnostic measures were developed for the clinical diagnosis of Alzheimer's disease (AD), the diagnosis would be still difficult in case of early stage of the disease. It could be inprove when the several parameters are simultaneously used for this purpose. We have done quantitative EEG analysis and MRI volumetry in 19 patients with AD and 15 healthy elderly volunteers. Global field power for the delta, theta-1, theta-2, alpha-1, alpha-2, beta-1, beta-2 and beta-3 bands in EEG and the volumes of the whole brain, left and right temporal lobes and left and right medial temporal lobes in 3-dimmensional MRI.Global field power for the delta and theta-1 band in AD significantly increased and that of alpha-1, beta-1 and beta-2 band decreased compared to healthy elderly. The whole brain, left and right temporal lobes, and left and right medial temporal lobes standardized by intra-cranial space significantly decreased in AD compared to healthy elderly. In a discriminant analysis (stepwise method), the left medial temporal lobe volume, alpha-1 global field power and theta-1 global field power were chosen as variances. Thirty two out of 34 subjects were correctly classified by the analysis. Only two healthy elderly were wrongly predicted. The reason of the successive result was that very different type of measures were used for the discrimination. For the EEG measures, global field power for the broad hands were used as functional parameters, and for the MRI measures, temporal and medial temporal lobe volumes were used as morphological measures. In conclusion, the combination of different measures were useful for the clinical diagnosis of AD.