Study on human cone system using long -and middle-wavelength sensitive cone electroretinagram and short-wavelength sensitive cone ERG

在本研究中，我们记录了正常人的长波长和中波长敏感视锥视网膜电信号(LM-CONE ERG)和短波敏视锥ERG(S-CONE ERG)，以观察视锥系统的发育和老化。此外，还记录了视网膜疾病患者的Lm-ERG和S-视锥ERG。Lm-视锥d波的发育早于其他成分，提示视网膜神经元膜电位的开启和关闭机制有不同的发育过程。Lm锥ERG a波较b波表现出更大的年龄相关性降低，提示非双极细胞对衰老的易感性。在凝固性静止性夜盲患者中，视锥ERG b波减弱，S视锥ERG消失，提示双极细胞功能障碍。然而，在Fishman报道的一种新疾病-单侧获得性夜盲中，我们发现保存了S视锥细胞的单侧获得性夜盲患者的Lm视锥b波减少。

In this study, we recorded long- and middle-wavelength sensitive cone electroretinogram (LM-cone ERG) and short-wavelength sensitive cone ERG (S-cone ERG) from normal subjects to investigate development and aging of the cone systems. Further, LM-and S-cone ERGs were recorded from patients with retinal diseases. LM-cone d-wave showed earlier development than other components, suggesting tht on- and off-mechanisms of the rmenbrane potential in the retinal neurons have different processes of development. LM cone ERG a-wave revealed greater age-related reduction than b-wave, indicating vulnerability of off-bipolar cell to aging. S-cone ERG showed slower developement and earlier age-related reduction than LM-cone ERG.In congetital stationally night blindness (CSNB), LM cone ERG b-wave diminished and S-cone ERG was gone, suggesting dysfunction of on-bipolar cells. However, in unilateral aquired night blindness, a new disease reported by Fishman, we found reduced LM-cone b-wave with preserved S-cone ERG.The mechanism of on-bipolar cell dysfunction is different between these diseases.