LUNG GROWTH AND MATURATION OF FETUS INCUBATED IN ARTIFICIAL PLACENTA

将妊娠125天左右的山羊胎儿置于胎儿ECMO系统中。体外循环持续时间平均为138小时。分析了ECMO术前和ECMO期间气管液中的表面活性物质和电解质。分析了ECMO前和ECMO后肺组织的表面活性物质和肺重量。还分析了ECMO前和ECMO中影响肺成熟的激素因素。ECMO中第5天气管液中磷脂、磷脂酰胆碱和卵磷脂的比例高于ECMO前。ECMO后肺组织的磷脂酰胆碱和活化的磷脂酰胆碱分别为72.3 mg/g和19.2 mg/gECMO后肺湿重和干重分别为87.8g和6.3g，显著高于ECMO前。ECMO期间血浆控制水平和T_3水平显著高于ECMO前。

The goat fetuses at about 125 days gestation were placed in the fetal ECMO system. The mean duration of A-V ECMO was 138 hours. The surfactant and electrolytes of the tracheal fluid were analyzed in pre-ECMO and during ECMO.The surfactant of lung tissue, and lung weight were analized in pre-ECMO and afte ECMO.Plasma cortisol and T3 levels were also assayd as hormonal factors that affected lung maturation in pre-ECMO and during ECMO.The phospholipid, phosphatidylcholine and lecithinsphingomeyelin ratio of the tracheal fluid on day 5 during ECMO were elevated above pre-ECMO.The phosphatidylcholine and disturacted phosphatidylcholine of the lung tissue after ECMO were 72.3mg/g and 19.2mg/g, which were significantly higher than pre-ECMO.The wet and dry lung weights after ECMO was 87.8g and 6.3g, which were significantly higher than pre-ECMO.Plasma control levels and T3 levels during ECMO were significantly higher than pre-ECMO.Electron microscopy demonstrated a higher increase of mature type II cells in the lung after ECMO than pre-ECMO.