The PHASER in focus

在过去的几十年里，核磁共振（NMR）和磁共振成像（MRI）已经成为物理和医学科学中的分析工具。它们的高信息含量使得从合成化学到临床诊断的应用成为可能。然而，尽管有这样强大的分析工具，NMR和MRI仍然存在固有的低灵敏度。通过超极化技术，信号可以增强1000倍以上。然而，可提取信息的精度和数量仍然有限。NMR光谱或图像的分辨率还取决于核自旋的可能观测时间。这种限制可以通过基于无线电波的激光器的兄弟--激光器来克服。本提案的目的是设计一个超高精度探测器的基础上仲氢超极化和RASER的概念。一个独一无二的设置，将被称为相位器（ParaHydrogen Achieves Super Enhanced Resolution）。相位器可以在低磁场下工作，这激发了小型化版本的设计。PHASER的设置将使NMR光谱学、微尺度MRI以及磁场、温度或旋转等外部参数测量的应用成为可能。

Over the past decades, nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) have consolidated as analytical tools in physical and medical sciences. Their high information content enabled applications from synthetic chemistry to clinical diagnosis. However, albeit such powerful analytical tools, NMR and MRI suffer from intrinsically low sensitivity. The signal can be boosted over 1000-fold by hyperpolarization technologies. However, precision and amount of the extractable information are still limited. The resolution of an NMR spectrum or image also depends on the possible observation time of the nuclear spins. This limit can be overcome by the RASER, a brother of the LASER based on radiowaves. The objective of this proposal is to design an ultra-high precision detector based on both parahydrogen hyperpolarization and the RASER concept. A one-of-a-kind setup that will be called the PHASER (ParaHydrogen Achieves Super Enhanced Resolution). The PHASER can be operated at low magnetic fields, motivating the design of a miniaturized version. The PHASER setup will enable applications in NMR spectroscopy, microscale MRI, and measurements of external parameters such as magnetic fields, temperatures or rotations.