The differences between the effects of oral potassium supplementation and magnesium supplementation on blood pressure and lipid metabolism in human subjects.

本研究的目的是研究补充钾(K)和补充镁（mg）对血压和脂质代谢的影响之间的差异。第一项研究（20名健康青年受试者）进行交叉研究（研究1），第二项研究（13名老年受试者）进行交叉研究（研究2）。在研究1中，受试者采用对照饮食（K 2g, Mg 250mg/d）并口服补充，所有受试者均在4周内分别口服Mg （Mg负荷：Mg 411mg/d）和K （K负荷：K 1.9g/d）。研究II受试者采用与研究i相同的方案，经k负荷后收缩压值明显下降。尿钾排泄量与钠排泄量（均以磨合值的百分比表示）在钾负荷上呈显著负相关。在Mg-loas中，尿去甲肾上腺素排泄量与尿Mg排泄量之间存在统计学上显著的负相关（以磨合值的百分比表示）。收缩压也因24小时去甲肾上腺素分泌减少而显著降低。补充Mg后，LCAT也有统计学上的显著增加。在mg负荷下，LCAT和HDL水平显著正相关，但在k负荷下没有出现这种情况。这些结果表明，mg负荷可能通过抑制抗过敏活性和诱导尿钠来降低血压，而k负荷可能通过尿钠来降低血压。此外，在mg负荷后，人类受试者的血脂也通过激活lCAT而改善。

The aim of this study was to examine the differences between the effects of potassium (K) supplementation and magnesium (mg) supplementation on both blood pressure and lipid metabolism. In the first study (consisting of 20 healthy yound subjects), a cross-over study was performaed (Study I), while the second study consisting of 13 elderly subjects (study II). In study I,the subjects consumed a control diet (K 2g, Mg 250mg/day) with oral supplementation and all thus received oral Mg supplementation (Mg-load : Mg 411mg/day) and K supplementation (K-load : K 1.9g/day) afor 4 weeks, respectively. The subjects in study II received the same protocol as that in study I.The sysotolic blood pressure values significanlty decrased after the K-load. A significantly negative correlation was observed between the urinary K excretion and sodium excretion (both expressed as a precentage of the run-in value) on the K-load. In the Mg-loas, there was a statistically significant negative correlation between the values for urinary noradrenaline excretion and urinary Mg excretion (expressed as a percentage of teh run-in value). The systolinc blood pressure also significantly decreased due to a reduction of the 24h-noradrenaline excretion. A statistically significant increase in LCAT was also observed after Mg supplementation. A significantly posotive correlation was observed between the levels of LCAT and HDL in the Mg-load, but this did not occur in the K-load. These results suggest that the Mg-load may lower blood pressure by suppressing the adregergic activity and also by possibly inducing natriuresis, while the K-load may decrease blood pressure through natriuresis. In addition, the serum lipid also improved through the activation of lCAT in human subjects after an Mg-load.