The Dietary Factor of Insulin Resistance ; Adiponectin and Saturated Fatty Acid

胰岛素抵抗的饮食因素；

• 批准号: 18500632
• 负责人: ITOH Kazue
• 金额: $ 2.4万
• 依托单位: Tenshi College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500632/
• 关键词: Insulin resistance; TNF-α; Adiponectin; High fat diet; High Saturated Fatty Acid; RLP-C; Human; Hs-CRP; 高飽和脂肪食; 食事管理下; RLP-C; アデイポネクチン; 食事管理化; 体脂肪量; レプチン

Insulin resistance is central for the etiology of the metabolic syndrome cluster of disease. Epidemiological and clinical evidence suggests that a high intake of dietary fat is associated with insulin resistance. Recently, the correlation of the insulin resistance and cytokine has been reported. The aims of this study were to clarify the effects of either amount of fat intakes or fatty acid composition on the postprandial plasma glucose level, the serum insulin response, and adipocytokine. Preliminary, ten healthy young females were consumed two isoenergestic study diets with a low fat (F-20:20% of total energy); a high fat (F-30:30%of energy), both of which had similar energy and protein contents (15% of total energy) for 5days, on separate occasions, at intervals of 3 weeks. On the last day, the meal tolerance test was consumed, therefore, blood sampling was done before and 30, 60, and 120 minutes after the test meals. The HOMA-R did not differ between F-20 and F-30. The TNF-α in F-3 … More 0 was significantly higher than that of F-20. A statistically significant positive correlations were observed between the TNF-α and the CRP, and the TNF-α and the body fat mass, respectively. Secondary, ten healthy young females were consumed two isoenergestic study diets with high fat (F-30:30%of total energy, S:M:P=3:4:3), a high saturated fatty acid (FB-30:30% fat of total energy, S:M:P=5:4:1), which had similar energy and protein contents (15% of total energy) for 5days, on separate occasions, at intervals of least 3 weeks. The HOMA-R did not change between F-30 and FB-30. The LDL-C in FB-30 was significantly higher than that of F-30. The triglyceride and the RLP-C levels at 120minutes after test meals were significantly greater in FB-30 compared to F-30. In addition, the significantly positive correlations were observed between the RLP-C and adiponectin level in both of F-30 and FB-30 diet. The TNF-α in FB-30 was significantly greater than in F-30, and there were positive correlation between the changes of TNF-α (FB-30/F-30)and that of HOMA-R level (FB-30/F-30). These results suggest that saturated fatty acid may play a key role in the development of insulin resistance due to increase the TNF-α level. Less

胰岛素抵抗是代谢综合征疾病群的核心病因。流行病学和临床证据表明，膳食脂肪的高摄入与胰岛素抵抗有关。近年来，胰岛素抵抗与细胞因子的相关性也有报道。本研究的目的是阐明脂肪摄入量或脂肪酸组成对餐后血糖水平、血清胰岛素反应和脂肪细胞因子的影响。首先，10名健康的年轻女性被消耗两种等能量研究饮食，低脂肪（F-20：总能量的20%）和高脂肪（F-30：能量的30%），两者具有相似的能量和蛋白质含量（总能量的15%），在不同的场合，间隔3周，持续5d。在最后一天，进行了膳食耐受性试验，因此，在试验餐前和试验餐后30、60和120分钟进行了血样采集。F-20和F-30之间的HOMA-R没有差异。F-3中的TNF-α ...更多信息 0显著高于F-20。TNF-α与CRP、体脂量之间均呈显著正相关。其次，10名健康年轻女性在不同的情况下，以至少3周的间隔，食用两种等能量研究饮食，其中高脂肪（F-30：总能量的30%，S：M：P=3：4：3），高饱和脂肪酸（FB-30：总能量的30%，S：M：P=5：4：1），其具有相似的能量和蛋白质含量（总能量的15%），持续5d。F-30和FB-30之间的HOMA-R没有变化。FB-30中的LDL-C显著高于F-30。试验餐后120分钟时，FB-30中的甘油三酯和RLP-C水平显著高于F-30。F-30和FB-30日粮中RLP-C与脂联素水平呈显著正相关。FB-30的TNF-α水平显著高于F-30，且TNF-α水平（FB-30/F-30）与HOMA-R水平（FB-30/F-30）的变化呈正相关。提示饱和脂肪酸可能通过增加TNF-α水平在胰岛素抵抗的发生发展中起重要作用。少

项目成果

肥満症治療ガイドラインダイジェスト版

肥胖治疗指南摘要版

• 发表时间: 2007
• 作者: 坂田 利家、斉藤 康、斉藤 昌之 編:立川 倶子、伊藤 和枝;他
• 通讯作者: 他