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Relationship between changes in the serum leptin and blood pressure after weight loss.

减肥后血清瘦素变化与血压的关系。

基本信息

批准号：
10680158
负责人：
ITOH Kazue
金额：
$ 1.92万
依托单位：
Nakamura Gakuen University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680158/
关键词：
Hypertension Obesity Leptin Insulin Resistance Visceral fat Norepinephrine Fat intake Sugar intake 血清レプチン閉経腹部脂肪

项目摘要

The aim of this study was to clarify the relationship between changes in the blood pressure and either the serum leptin level or the insulin level in moderately obese females. One-hundred two(BMI 29.5±0.5kg/m^2, age 47.0±0.9), who were nondiabetic and did not receive any medication during a 3 month period under dietary and exercise therapy. We measured the abdominal total fat, serum leptin and 75gOGTT before and after weight loss. The subjects were classified into HT(n=31)and NT(n=71)group. No differences regarding age, fat-mass, visceral fat, HOMA, ΣIRI, PRA or 24hU-NE were observed between the HT and the NT before weight loss, but the basal serum leptin was significantly higher in the HT than in the NT.After a 3 month weight reduction program, the abdominal total fat, serum leptin and ΣIRI significantly decreased in both groups. The SBP/DBP significantly decreased from 144//84 to 130/77 mmHg only in the HT but not in the NT.The PRA decreased in both groups, while the 24hU-NE signific … More antly decreased only in the HT.The changes in the ΣIRI and leptin level significantly correlated to the changes in visceral fat after weight loss in both groups. A significantly positive correlation was observed between the changes of visceral fat and changes of simple carbohydrate and fat intakes after weight loss. The changes in the leptin level significantly correlated to the changes in both ΣIRI and HOMA after weight loss in the two groups, respectively. Finally, a statistically significant positive correlation was observed between the changes in the leptin and the changes in the MBP only in the HT.A multiple regression analysis showed the changes in MBP to be independently associated with the changes in 24hU-NE and the changes in either ΣIRI or HOMA in all subjects. However, a statistically significant positive correlation was observed between the changes in the MBP and changes in the leptin even after adjusting for the total abdominal fat, 24hU-NE and either ΣIRI or HOMA in a multiple regression analysis only in the HT group. Less

这项研究的目的是阐明中度肥胖女性的血压变化与血清瘦素水平或胰岛素水平之间的关系。102例（BMI 29.5±0.5kg/m^2，年龄47.0±0.9），非糖尿病患者，在饮食和运动治疗的3个月内未接受任何药物治疗。测定减肥前后腹部总脂肪、血清瘦素和75gOGTT。将患者分为HT组（n=31）和NT组（n=71）。减肥前HT组和NT组在年龄、脂肪量、内脏脂肪、HOMA、ΣIRI、PRA或24hU-NE方面没有差异，但HT组的基础血清瘦素明显高于NT组。减肥3个月后，两组的腹部总脂肪、血清瘦素和ΣIRI均显著下降。高血压组收缩压/舒张压由144/ 84降至130/77 mmHg，而高血压组收缩压/舒张压明显降低，而高血压组收缩压/舒张压明显降低。两组体重减轻后，ΣIRI和瘦素水平的变化与内脏脂肪的变化显著相关。减肥后内脏脂肪的变化与简单碳水化合物和脂肪摄入量的变化呈显著正相关。瘦素水平的变化分别与两组体重减轻后ΣIRI和HOMA的变化显著相关。最后，仅在HT中，瘦素的变化与MBP的变化之间存在统计学上显著的正相关。多元回归分析显示，所有受试者中MBP的变化与24hU-NE的变化以及ΣIRI或HOMA的变化独立相关。然而，在多元回归分析中，仅在HT组中，即使在调整了总腹部脂肪、24hU-NE和ΣIRI或HOMA后，MBP的变化与瘦素的变化之间仍存在统计学上显著的正相关。少