A humanised sensory neuron high-throughput screening platform

感觉神经元负责将触摸或温度等外部刺激转化为分级电信号，使我们能够与周围的世界互动。然而，与其他类型的细胞不同，感觉神经元不能增殖，因此必须从人类身体或动物身上取出，才能研究它们的药理和功能。这限制了我们理解神经元信号通路的能力。该项目旨在利用来自人类干细胞的感觉神经元来开发和优化可用于研究体外培养的人类感觉神经元的药理学和功能的分析方法。这增强了对关键模型系统和技术平台的访问，并消除了将细胞与身体隔离的需要。

Sensory neurons are responsible for converting external stimuli such as touch or temperature into graded electrical signals that allow us to interact with the world around us. However, unlike other cell types, sensory neurons cannot proliferate and thus must be removed from human cadavers, or animals, in order to study their pharmacology and function. This limits our ability to understand neuronal signalling pathways. This project aims to use sensory neurons derived from human stem cells to develop and optimise assays that can be used to study the pharmacology and function of human sensory neurons in vitro. This enhances access to critical model systems and technology platforms and removes the need for isolation of cells from cadavers.