Dynamic Stereocontrol

从1998年到2000年，“动态立体控制”研究项目已经成功地进行了三年，并获得了动态立体控制的新概念，并发明了用于有机反应的立体控制、活性物种的生成(如自由基和卡宾)和手性分离的新方法。该项目的代表性成果是：1)利用新型手性双齿路易斯酸催化剂立体控制羰基化合物的反应；2)通过动态控制非手性催化剂的构象构建不对称反应中心；3)探索光活化的新型不对称催化剂；4)通过非手性配体的协同作用增强手性催化剂的不对称诱导能力；5)开发水介质中的自由基反应；6)碳正离子物种的立体控制和环状化合物的合成新方法；7)顺序生成…更多的碳自由基和碳负离子：反应序列中的动态立体控制，)构建用于薄层色谱的手性固定相，9)分子机器的开发，一种光能手性分子马达。此外，通过开幕研讨会对项目成果进行了粗略的讨论。通过对这些讨论和评价结果的分析，认识到这些成果对有机合成和手性分离的进步，特别是对立体控制和分子识别的发展做出了巨大贡献。通过分析，也认识到继续推广动态立体控制的必要性，这将为生态上可接受的、原子效率高的合成化学和生产完全光学纯材料奠定基础。本研究的报告将以《动态立体控制各自的研究成果》的研究报告发表。较少

Research Project "Dynamic Stereocontrol" has been successfully carried out for three years from 1998 to 2000 and rewarded with acquisition of new concepts for dynamic stereocontrol and invention of new methodologies for stereocontrol of organic reactions, generation of active species such as radical and carbene, and chiral separation. Representative achievements of the project are i) stereocontrol of reactions of carbonyl compounds by using a conceptually new chiral bidentate Lewis acid catalyst, ii) Construction of asymmetric reaction site by dynamic control of the conformation of achiral catalyst, iii) exploration of new type of asymmetric catalyst activated by photo-irradiation, iv) enhancement of asymmetry inducing ability of chiral catalyst by synergistic influence of achiral ligand, v) exploitation of radical reaction in aqueous medium, vi) stereocontrol of carbocation species and introduction of new methodology for construction of cyclic compounds, vii) sequential generation of … More carbon radicals and carbanions : dynamic stereocontrol in the reaction sequence, viii) construction of chiral stationary phases (CSPs) for thin layer chromatography (TLC), ix) development of molecular machine, a light-powered chiral molecular motor.In the present reasearch, the achievements obtained in the project were collected and evaluated by the research members including many distinguished chemists in our country. Furthermore, the results of the project were thouroughly discussed through the opened symposium. Based on the analysis of the results by these discussions and evaluation, the achievements were recognized to have greatly contributed to advancement of organic synthesis and chiral separation, especially to development of stereocontrol and molecular recognition.From the analysis, the necessity of continuing promotion of dynamic stereocontrol which will lay a foundation for ecologically acceptable, atom-efficient and high-yielding synthetic chemistry and for production of completely optically pure materials was also recognized.Report of the present research will be published as the research report entitled "Reseach on Dynamic Stereocontrol." Less