Control of Self-Organization of Amphiphilic Polymers by Macromolecular Architecture

We designed and synthesized amphiphilic random copolymers as follows ： （1） To clarify "the character" of the hydrophobe， we synthesized amphiphilic random copolymers of sodium 2-（acrylamido）-2-methylpropanesulfonate（AMPS） and methacrylamides substituted on the N-position with saturated or unsaturated hydrocarbons by radical copolymerization with various N-substituted methacrylamides contents。（2）研究氢磷和聚合物主链之间的间隔绑定效应，我们将AMPS与十二烷基甲基甲基丙烯酸酯或与N-十二烷基-甲基丙烯酸酰胺结合在一起的径向随机共聚物。Furthermore， we synthesized random copolymers of AMPS and methacrylates bearing-O （CH-D22-D22-D2O）-D2n-D212-D225-D2 with several n values。We investigated the self-organization process of these amphiphilic polymers， and characterized the structures and properties of the nano-particles formed by these polymers。（1）《纳米粒子的羟基微区域的性质》，如微观动力学，由稳定状态和时间依赖的荧光技术利用荧光聚合物进行调查。（2）纳米粒子的氧化辐射是由静态光散射确定的。纳米粒子的氢动力学大小是由准性光散射、凝胶渗透色谱法和毛细管电泳法估计的。（3）纳米粒子的宏观动力学是由质量光散射和流变学调查的。（4）纳米粒子的形态学是由传输电子显微镜观察的。这些结果显示，径向聚合物的自我组织是由设计的宏观分子结构因子所控制的，其中含有氢氧化物单体、氢氧化物和氢氧化物和分子链主要之间的空间结合。

We designed and synthesized amphiphilic random copolymers as follows : (1) To clarify "the character" of the hydrophobe, we synthesized amphiphilic random copolymers of sodium 2- (acrylamido) -2-methylpropanesulfonate (AMPS) and methacrylamides substituted on the N-position with saturated or unsaturated hydrocarbons by radical copolymerization with various N-substituted methacrylamides contents. (2) To investigate the effect of the spacer bonding between the hydrophobe and the polymer main chain, we synthesized amphiphilic random copolymers of AMPS with dodecyl methacrylate or with N-dodecyl-methacrylamide. Furthermore, we synthesized random copolymers of AMPS and methacrylates bearing-O (CHィイD22ィエD2CHィイD22ィエD2O)ィイD2nィエD2CィイD212ィエD2HィイD225ィエD2 with several n values.We investigated the self-organization process of these amphiphilic polymers, and characterized the structures and properties of the nano-particles formed by these polymers. (1) The properties for the hydrophobic microdomains of the nano-particles, such as microscopic dynamics, were investigated by steady-state and time-dependent fluorescence techniques using the fluorophore-labeded amphiphilic polymers. (2) The radii of gyration for the nano-particles were determined by static light scattering. The hydrodynamic sizes of the nano-particles were estimated by quasielastic light scattering, gel-permeation chromatography, and capillary electrophoresis. (3) Macroscopic dynamics of the nano-particles were investigated by quasielastic light scattering and rheometry. (4) Morphology of the nano-particles was observed by transmission electron microscopy.These results show that the self-organization of amphiphilic polymers is controlled by design of macromolecular structural factors containing the contents of hydrophobic monomers, the hydrophobes, and the spacer bondings between the hydrophobes and polymer main chain.