Establishing Design Principles Of Polymers For Intracellular Delivery

工程聚合物通过实现有针对性的纳米级细胞相互作用，在生物纳米技术领域发挥了核心作用。细胞内给药领域的进展目前受到一个主要瓶颈的影响，这是因为缺乏适用于各种双分子货物的有效聚合物。本质上，取决于货物的类型：DNA、RNA或蛋白质，聚合物需要可编程性。传统聚合物试剂的可调性有限，不适合这一特殊应用。这项多学科项目通过设计新的已定义聚合物纳米级试剂序列来解决这一重大问题，以实现在细胞中的有效输送。

Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.