The role of verotoxin receptors (Gb3) in the infection of O-157

产生韦罗毒素的大肠杆菌O157被确定为溶血性尿毒症综合征（HUS）的病原体。据报道，这些综合征是由蛇毒毒素与其受体糖脂球三酰神经酰胺（Gb3）结合引起的血管内皮细胞损伤引起的。讨论了人体中Gb3的分布或水平因年龄和性别的不同而不同的可能性。因此，在本研究中，我们通过组织学检查Gb3抗原在不同年龄和性别的人脑和肾脏中的表达，以阐明Gb3受体的定位是否与血管内皮损伤的发生有关。结果：虽然Gb3的分布或水平存在许多个体差异，但在性别上分布无明显差异，但与成人组相比，婴儿组Gb3有较强的组织学反应。

Verotoxin producing Escherichia coli O157 was identified as a causative agent of hemolytic uremic syndrome (HUS). These syndrome was reported to be caused by vascular endothelial cell damage by the binding of verotoxin to its receptor glycolipid globotriaosylceramide (Gb3). It is well discussed about the possibility that the Gb3 distributions or levels are various different due to the factor of age and sex in human. So in this study, we histologically examined the expression of the Gb3 antigen on human brain and kidney of various age and both sexes in order to clarify whether the localizations of Gb3 receptor related to the development of vascular endothelial damage. Results : Although there were many individual differences about the distributions or levels of Gb3, there were no significant differences in the distributions of Gb3 owing to the sex, but there were strong histological reactions of Gb3 in infant group compare to the adult group.