STUDY ON THE ANIMAL CRUDE DRUGS, ESPECIALLY LIPID COMPOSITION.

本研究旨在从动物生药中寻找药物设计的先导化合物。从亚洲地龙中分离得到4种甘油磷胆碱和4种糖鞘糖脂。根据化学和波谱数据确定了它们的结构。对海葵Actiniogeton sp.的总脂进行了分析，分离得到了1，2-环缩醛-3-甘油-3-磷乙醇胺。他们被发现是所谓的费尔根氏乙酰磷脂，被认为是源自原始血浆原的人工制品。我们检测了这些化合物在动物组织中是否为完整的成分，并获得了可靠的确认，即它们通常存在于海葵中。从蝉的壳中分离得到6个具有光学活性的具有1，4-苯并二恶烷骨架的N-乙酰基多巴胺二聚体。根据核磁共振和圆二色谱确定了它们的结构，包括绝对构型。从蜈蚣中分离得到两个喹啉硫酸盐，并对它们的结构进行了表征。本研究中分离的新化合物有望具有独特的生物活性，我们将对它们的活性进行检测。

This study was undertaken to search for lead compounds of drug design from animal crude drugs.1. Four glycerophosphocholines together with four glycosphingolipids were isolated in pure state from the earthworm, Pheretima asiatica. Their structures were determined on the bases of chemical and spectral data.2. The total lipid fraction obtained from the sea anemone, Actiniogeton sp.was analyzed, and 1,2-cyclic acetal type sn-glycero-3-phosphoethanolamines were isolated. They were revealed to be so-called Feulgen's acetalphosphatides, which have been regarded as artifacts derived from original plasmalogens. We examined whether these compounds are intact constituents in the animal tissues, and obtained reliable confirmation that they are normally present in the sea anemone.3. Six optically active N-acetyldopamine dimers having 1,4-benzodioxane skeleton were obtained from cast-off shell of the Cicada, Cryptotympana sp. Their structures including absolute configurations were determined on the bases of NMR and circular dichroism spectroscopic data.4. Two quinoline sulfates were isolated from the centipede, Scolopendra subspinipes multidens L.Koch, and their structures were characterized.Novel compounds isolated in this study are expected to have unique biological activities, their activities will be examined.