A Magnetic Fluid-Driven Artificial Heart
A Magnetic Fluid-Driven Artificial Heart
批准号:
10680800
负责人:
MITAMURA Yoshinori
金额:
$2.43万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 1999
中文摘要
各种植入式人工心脏已被研究。然而,它们都有一个共同的缺点,即使用轴承和复杂的驱动机构。另一方面,磁流体执行器直接通过施加磁场来驱动磁流体,而不需要轴承。研究了磁流体驱动人工心脏的可行性。两个气隙为10毫米的环形螺线管被安排在丙烯酸管(10 mmOD, 7.4 mmID)附近。一个小气球(体积:2mL)连接在丙烯酸管的两端。气球被包裹在一个坚硬的盒子里,盒子里有入口和出口。丙烯酸管和气球都充满了氟惰性物质。将磁性流体和一个铁圆筒浸入氟惰性液体中。两个螺线管根据计算机发出的控制信号交替激活。进行了两个实验:(1)单独使用磁流体。(2)磁流体与铁缸结合使用。这种组合被用作高磁化的磁流体的替代品。单独使用磁流体时,在140次/分钟下可获得26 mL/min的流量。闭合压为13mmhg。使用磁流体和铁筒,在260次/min下获得318 mL/min的流量。闭合压力为300 mmHg。采用磁流体配合铁缸,可获得90%的最大流量。计算表明,使用磁化强度为113千卡/米的磁流体可获得超过100毫米汞柱的驱动压力。如果研制出磁化强度为113 kA/m的磁流体,磁流体驱动的人工心脏是可行的。
英文摘要
A variety of implantable artificial hearts have been studied. They, however, have a common drawback of utilizing bearings and a complicated driving mechanism. A magnetic fluid actuator, on the other hand, drives magnetic fluids directly simply by applying magnetic field and does not require a bearing. Feasibility of a magnetic fluid-driven artificial heart was studied.Two ring solenoids with an air gap of 10 mm were arranged near an acrylic tube (10 mmOD, 7.4 mmID). A small balloon (volume: 2mL) was connected to the both ends of the acrylic tube. The balloon was encased in a rigid box that had an inlet and outlet port. The acrylic tube and the balloons were filled with Fluorinert. Magnetic fluid and an iron cylinder were immersed in Fluorinert. Two solenoids were alternately activated according to control signals from a computer. Two experiments were conducted: (1) magnetic fluids alone were used. (2) A combination of magnetic fluids and the iron cylinder was used. This combination was used as a substitute for magnetic fluids with high magnetization.With the use of magnetic fluids alone, a flow of 26 mL/min was obtained at 140 beats/min. Closing pressure was 13 mmHg. With the use of magnetic fluids and the iron cylinder, a flow of 318 mL/min was obtained at 260 beats/min. Closing pressure of 300 mmHg was obtained.With the use of magnetic fluids and the iron cylinder, 90 % flow of the maximum flow was obtained. Calculation disclosed that a driving pressure over 100 mmHg is obtained with the use of magnetic fluids with a magnetization of 113 kA/m.A magnetic fluid-driven artificial heart could be feasible if magnetic fluids with a magnetization of 113 kA/m are developed.
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Y. Mitamura: "Magnetic fluid-driven artificial heart"Proceedings of 11th Symposium on Electromagnetics and Dynamics. 61-64 (1999)
Y. Mitamura:“磁流体驱动的人工心脏”第11届电磁学与动力学研讨会论文集。
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三田村好矩: "磁性液体の人工臓器への応用"人工臓器. 28・3. 618-623 (1999)
三田村义典:“磁性液体在人工器官中的应用”人工器官28・3(1999)。
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Y. Mitamura: "A magnetic fluid-driven blood pump"Proceedings of 4th Asian-Pacific Conference on Medical & Biological Engineering. 220 (1999)
Y. Mitamura:“磁流体驱动血泵”第四届亚太医学会议论文集
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三田村 好矩: "磁性流体駆動人工心臓"第11回「電磁力関連のダイナミックス」シンポジウム講演論文集. 61-64 (1999)
Yoshinori Mitamura:“磁流体驱动人工心脏”第 11 届“电磁力相关动力学”研讨会论文集 61-64(1999 年)。
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Treatment for diabetic retinopathy targeting cyclin-dependent kinase 5
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批准号:19K09951
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
-
财政年份:2019
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负责人:MITAMURA Yoshinori
-
依托单位:
PPAR gamma-mediated role of cyclin-dependent kinase 5 in the pathogenesis of proliferative diabetic retinopathy
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批准号:16K11288
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:MITAMURA Yoshinori
-
依托单位:
Diabetic retinopathy treatment targeting PPAR gamma
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批准号:25462717
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2013
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负责人:MITAMURA Yoshinori
-
依托单位:
Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy
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批准号:22591929
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2010
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负责人:MITAMURA Yoshinori
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依托单位:
Regulation of the angiogenesis in proliferative diabetic retinopathy using promyelocytic leukemia tumor suppressor (PML)
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批准号:19592005
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2007
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负责人:MITAMURA Yoshinori
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依托单位:
The role of transcriptional factor in neovascularization of proliferative diabetic retinopathy
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批准号:17591846
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:MITAMURA Yoshinori
-
依托单位:
Development of an axial flow blood pump using a hydrodynamic pressure bearing
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批准号:14380386
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.69万
-
财政年份:2002
-
负责人:MITAMURA Yoshinori
-
依托单位:
Development of a ceramic heart valve
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批准号:60870045
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$6.34万
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财政年份:1985
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负责人:MITAMURA Yoshinori
-
依托单位:
海外基金