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Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy

Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy
早幼粒细胞白血病肿瘤抑制剂作为糖尿病视网膜病变的治疗剂
批准号:
22591929
负责人:
MITAMURA Yoshinori
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Promyelocytic leukemia tumor suppressor (PML) mRNA expression levels in membrane samples, and the PML protein concentrations in aqueous humor and vitreous fluid samples were significantly lower in PDR patientsthan control patients. We observed a statistically significant inverse correlation between the concentrations of PML and vascular endothelial growth factor in the aqueous humor and vitreous fluid of PDR patients. Taken together, PML may be a good candidate as a diagnostic marker and a therapeutic agent for PDR.
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DOI: 10.1016/j.diabres.2012.09.020
发表时间: 2012-11-01
期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
影响因子: 5.1
作者: [Katome, Takashi, Namekata, Kazuhiko, Mitamura, Yoshinori]
通讯作者: Mitamura, Yoshinori
DOI: 10.2152/jmi.59.1
发表时间: 2012
期刊: The journal of medical investigation : JMI
影响因子: --
作者: [Y. Mitamura;Sayaka Mitamura-Aizawa;Toshihiko Nagasawa;Takashi Katome;H. Eguchi;T. Naito]
通讯作者: Y. Mitamura;Sayaka Mitamura-Aizawa;Toshihiko Nagasawa;Takashi Katome;H. Eguchi;T. Naito
増殖糖尿病網膜症の眼内におけるPML発現の解析
增殖性糖尿病视网膜病变眼部PML表达分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yoshida-Hata N, et al, 香留崇, 香留崇]
通讯作者: 香留崇
DOI: 10.1155/2013/518170
发表时间: 2013
期刊: Journal of ophthalmology
影响因子: 1.9
作者: [Mitamura Y, Mitamura-Aizawa S, Katome T, Naito T, Hagiwara A, Kumagai K, Yamamoto S]
通讯作者: Yamamoto S
7
    Treatment for diabetic retinopathy targeting cyclin-dependent kinase 5
    • 批准号:
      19K09951
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2019
    • 负责人:
      MITAMURA Yoshinori
    • 依托单位:
    PPAR gamma-mediated role of cyclin-dependent kinase 5 in the pathogenesis of proliferative diabetic retinopathy
    • 批准号:
      16K11288
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2016
    • 负责人:
      MITAMURA Yoshinori
    • 依托单位:
    Diabetic retinopathy treatment targeting PPAR gamma
    • 批准号:
      25462717
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2013
    • 负责人:
      MITAMURA Yoshinori
    • 依托单位:
    Regulation of the angiogenesis in proliferative diabetic retinopathy using promyelocytic leukemia tumor suppressor (PML)
    • 批准号:
      19592005
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2007
    • 负责人:
      MITAMURA Yoshinori
    • 依托单位:
    海外基金