Promyelocytic leukemia tumor suppressor as therapeutic agent for diabetic retinopathy

早幼粒细胞白血病肿瘤抑制剂作为糖尿病视网膜病变的治疗剂

• 批准号: 22591929
• 负责人: MITAMURA Yoshinori
• 金额: $ 2.83万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591929/
• 关键词: 外科; 細胞・組織; 生体分子; 糖尿病; 臨床

Promyelocytic leukemia tumor suppressor (PML) mRNA expression levels in membrane samples, and the PML protein concentrations in aqueous humor and vitreous fluid samples were significantly lower in PDR patientsthan control patients. We observed a statistically significant inverse correlation between the concentrations of PML and vascular endothelial growth factor in the aqueous humor and vitreous fluid of PDR patients. Taken together, PML may be a good candidate as a diagnostic marker and a therapeutic agent for PDR.

早幼粒细胞白血病肿瘤抑制因子(PML)基因在PDR患者房水和玻璃体积液中的表达水平及PML蛋白浓度均显著低于对照组。我们观察到PDR患者房水和玻璃体积液中PML浓度与血管内皮生长因子浓度呈显著负相关。综上所述，PML可作为PDR的诊断标记物和治疗剂。

项目成果

Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy

• DOI: 10.1016/j.diabres.2012.09.020
• 发表时间: 2012-11-01
• 期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
• 影响因子: 5.1
• 作者: Katome, Takashi;Namekata, Kazuhiko;Mitamura, Yoshinori
• 通讯作者: Mitamura, Yoshinori

Diagnostic imaging in patients with retinitis pigmentosa.

• DOI: 10.2152/jmi.59.1
• 发表时间: 2012
• 期刊: The journal of medical investigation : JMI
• 作者: Y. Mitamura;Sayaka Mitamura-Aizawa;Toshihiko Nagasawa;Takashi Katome;H. Eguchi;T. Naito

増殖糖尿病網膜症の眼内におけるPML発現の解析

增殖性糖尿病视网膜病变眼部PML表达分析

• 发表时间: 2012
• 作者: Yoshida-Hata N;et al;香留崇;香留崇
• 通讯作者: 香留崇

Photoreceptor impairment and restoration on optical coherence tomographic image.

• DOI: 10.1155/2013/518170
• 发表时间: 2013
• 期刊: Journal of ophthalmology
• 影响因子: 1.9
• 作者: Mitamura Y;Mitamura-Aizawa S;Katome T;Naito T;Hagiwara A;Kumagai K;Yamamoto S
• 通讯作者: Yamamoto S

増殖糖尿病網膜症の眼内における PML 発現の解析

增殖性糖尿病视网膜病变眼部PML表达分析

• 发表时间: 2012
• 作者: Yoshida-Hata N;et al;香留崇
• 通讯作者: 香留崇