Substitution Reactions of Rhenium Complexes

1.以dichloroethoxyoxobis(triphenylphosphine)rhenium(V)([ReOCl_2(OEt)(PPh_3)_2])Dichloroethoxyoxobis(triphenylphosphine)rhenium(V)的碱解为起始原料，合成了Re(V)和Re(IV)配合物。在含有[ReOCl2(OEt)(PPh_3)_2]的氯仿溶液中加入氢氧化钠水溶液，引发碱解反应。用分光光度法测定有机相中Re的浓度。根据表观速率常数与氢氧离子浓度的关系，表观速率常数可表示为κ_&lt；upp&gt；=κ[OH]，其中κ是[ReOCl2(OEt)(PPh_3)_2]碱解的速率常数。由此确定了反应速率常数κ为κ=1.03X10^-4；M^&lt；-4；S^-1。(25℃，Ι=1.0M)2.多示踪剂溶液中Re、Tc及其他必需微量元素的摄取与分布Re几乎完全被大鼠体内吸收。但它很快就会从尿液中排出。因此，要研究稀土配合物在大鼠体内的取代反应是非常困难的。体内吸收速率低于Re，但也表现出快速消除行为。给缺锌小鼠灌胃另一种含TC的示踪液时，缺锌小鼠对TC的摄取速率低于正常小鼠。

1. The base hydrolysis of dichloroethoxyoxobis(triphenylphosphine)rhenium(V) ([ReOCl_2(OEt)(PPh_3)_2])Dichloroethoxyoxobis(triphenylphosphine)rhenium(V) has been used for the synthesis of Re(V) and Re(IV) complexes as a starting material. An aqueous solution of sodium hydroxide was added to a chloroform solution containing [ReOCl_2(OEt)(PPh_3)_2] to initiate the base hydrolysis reaction. The concentration of rhenium in the organic phase was determined spectrophotometrically. On the basis of the dependence of the apparent rate constant on the concentration of hydroxide ion, the apparent rate constant could be expressed as κ_<upp> = κ [OH], where κ is the rate constant for the base hydrolysis of [ReOCl_2(OEt)(PPh_3)_2]. Thus the rate constant κ was determined to be κ = 1.03 X 10^<-4> M^<-4>s^<-1>. (25 ℃, Ι= 1.0 M)2. Uptake and distribution of Re, Tc and other essential trace elements in multitracer solutionsA multitracer solution including Tc and Re, chemically separated from gold target, was orally administered to rats. Rhenium was almost completely absorbed into rats' bodies. But it excreted in urine rapidly. Therefore, it was too difficult to investigate the substitution reactions of rhenium complexes in rats' bodies. Rapid elimination behavior was also observed for Tc although its absorption rate into their bodies was less than that of Re. When another tracer solution including Tc was administered orally to Zn-deficient mice, the uptake rate of Tc into Zn-deficient mice was lower than that of control (normal) mice.