Research on circadian variations of biological variables, such as blood pressure, body temperature, etc, in different sleep-wake patterns II

为了研究生物学变量的昼夜变化，当睡眠相位改变时，七名男性学生（平均年龄为10岁）。1999年，在控制的物理条件和生活环境下，对21.1岁，169.5厘米，65.8公斤）进行了连续72小时的研究。第1天睡眠时间为00：00 ~ 07：00，第2天为0，第3天为12：00 ~ 19：00，血压和脉率在睡眠低谷期有明显的双相变化，并迅速调整到新的作息时间。受试者对昼夜节律变化的调整以不同的速率发生。口腔温度和皮质醇在3天内保持显著的昼夜节律变化，每天相位延迟2小时。一些血液和尿液变量在相移后表现出具有钝化幅度的组合变化，在不同变量中以不同速率调整昼夜变化。主观警觉性在长时间睡眠中迅速降低，而在转移睡眠后恢复得更慢且更不有效。我们调查了310名大学生的日常生活时间。在假期里，他们醒来。比平日晚1 ~ 2小时。70%的人在工作日吃早餐，49%的人在假日吃早餐。那些没有吃早餐的人醒来后，我们将进一步分析所检查变量的节律特征，并探索变量或时间之间的关系，考虑到个体间的变异性，并报告结果。

To investigate the changes revealed in circadian variations of biological variables, when a sleep phase was shifted, seven male students (ave. 21.1yo, 169.5cm, 65.8kg) were studied for 72 hours continuously under a controlled physical conditions and living environment in 1999. Sleep hours were from 00:00 to 07:00 on the 1st day, zero on the 2nd day, and from 12:00 to 19:00 on the 3rd day.Blood pressure and pulse rate had the clear biphasic variation with the low period during sleep, and adjusted abruptly to the new schedule. Adjustment of circadian variations to changed sleep-wake schedules occurred at different rates by subject. Oral temperature and cortisol kept significant circadian variations for 3 days, with the phase delay of 2 hours per day. Some blood and urinary variables showed combined variations with blunted amplitudes after the phase shift, with adjustment of circadian variations at different rates in the different variables. Subjective vigilance lowered rapidly during prolonged night, and recovered more slowly and less effectively after the shifted sleep. The reactions to the phase shift also depended on persons.We surveyed timings of daily life in 310 university students. On holidays they woke up ca. 1〜2 hours later than on weekdays. 70% of them had breakfast on weekdays, and 49% on holidays. Those who did not eat breakfast woke up ca. 2 hours later than those who had breakfast.We will further analyze rhythmometric characteristics of variables examined, and explore the relations between variables or symptomes, taking into account of interindividual variability, and will report the results.