High frequency Stinulation fo reduce muscle fatigue in functional electhiccl Sfimu lation

我们评估了高频电刺激对大鼠脊髓横断后急性肌萎缩的预防作用。测量1、2A和2B型肌纤维的小纤维直径。在另一项评估中，测量最大收缩力。在20和100Hz时产生的肌肉力在强直力中表示为递增值（IV）。在未刺激和刺激的胫前肌（TA）比较中，治疗性电刺激（TES）可以防止刺激水平下1型纤维（p < 0.01）和2B型纤维（p < 0.05）以及100Hz水平下2A型纤维（p < 0.05）的萎缩。在100 Hz时，2A型和2B型的非刺激和刺激肌肉的肌纤维直径大小有显著差异。100Hz时肌力的增加值显著大于20Hz时（p < 0.05）。在三种肌肉类型的高频和低频刺激纤维之间没有观察到明显的组织学差异。我们得出结论，高（100Hz）频率刺激比无或低（20Hz）频率刺激更有效地预防急性肌纤维萎缩，且高频率刺激下肌力的增加值明显大于低频率刺激，提示未来的研究，包括高频刺激在急性脊髓损伤中的临床应用。

We evaluated the effects of high frequency electrical stimulation for preventing acute muscle atrophy after spinal cord transection in rats. The lesser fiber diameters from type 1, 2A and 2B muscle fibers were measured. In another assessment, maximal contraction force was measured. The muscle force produced at 20, and 100Hz was expressed as increasing values (IV) in tetanic force. In the comparison between non-stimulated and stimulated Tibialis Anterior (TA) muscles, the atrophy of type 1 fibers (p < .01) and type 2B fibers (p < .05) at both stimulated levels and of type 2A fibers at 100Hz level (p < .05) were preventedby therapeutic electrical stimulation (TES). There were significant differences in the size of muscle fiber diameter between non-stimulated and stimulated muscles at 100 Hz in type 2A and, markedly, in type 2B. The increasing value of muscle force was significantly greater at 100Hz than at 20Hz (p < .05). No significant histological differences were observed between high and low frequency stimulated fibers of any of the three muscle types. We concludes that acute atrophy of muscle fibers was more effectively prevented by high (100Hz) frequency stimulation than no or low (20Hz) frequency stimulation, and the increasing value of muscle force was significantly greater at high frequency stimulation than low frequency stimulation, suggesting that future studies, including the clinical application of high frequency stimulation to acute spinal cord injury, should be conducted.