bone replacement of apatite cement with the connected open pore

为了开发更快替代骨的磷灰石骨水泥，我们制备了具有连通开孔的磷灰石骨水泥，并对其进行了物理性能和组织学检测。连接的开口孔应使用不锈钢管路制造。首先，用2片亚克力板形成直径与不锈钢线一致的孔，并将其制成连接的开孔制造设备。不锈钢线通过上述2片亚克力板材的相遇贯穿每一个孔。接下来，将磷灰石水泥混合后，在钢丝的缝隙中紧密填充水泥，在温箱中100%相对湿度下保存24小时。然后谨慎地将丙烯板和不锈钢线分离，制成样品，观察到无论是丙烯酸还是不锈钢，磷灰石骨水泥中都形成了羟基磷灰石。接下来，机械…S根据径向抗拉强度(DTS)评价固化磷灰石水泥试件的强度。结果表明，当不锈钢直径大于0.7 mm时，其机械强度显著降低。对于厚度小于0.4 mm的不锈钢，制样难度较大。因此，不锈钢管线直径以0.5~0.6 mm为宜。将连通开孔的磷灰石骨水泥植入兔胫骨内，进行组织学检查。结果表明，在骨水泥与软组织的界面上，骨水泥周围有较薄的纤维组织，炎症反应轻微，可见少量异物巨细胞。与骨界面处无软组织，新骨侵入连通的开孔内，部分形成骨髓。结果表明，开孔形成后，骨表面积增大，与骨界面增大，磷灰石水泥与连通的开孔磷灰石水泥迅速替代骨。较少

In order to develop apatite cement which more quickly replaces the bone, we fabricated apatite cement with the connected open pore and carried out the physical property and histological examination. The connected open pore should be produced using the stainless steel line. To begin with, the hole which agreed for the diameter of the stainless steel line with 2 sheets of the acrylic board was formed, and it was made to be the connected open pore manufacture equipment. The stainless steel line was run through each hole by the encounter of the acrylic board of above-mentioned 2 sheets. Next, after the apatite cement is mixed and the gap of the steel wire is closely filled with the cement, it keeped in an incubator for 24 hour at 100% relative humidity. The acrylic board and stainless steel line were prudently detached afterwards, and it was made to be a sample.The formation of hydroxyapatite from apatite cement was observed regardless of acrylic and stainless steel. Next, the mechanical s … More trength of set apatite cement specimens was evaluated in terms of diametral tensile strength (DTS). As the result, when the diameter of stainless steel is thicker than 0.7mm, the mechanical strength remarkably decreased. The preparation of the sample was difficult for the stainless steel which was thinner than 0.4mm. Therefore, 0.5〜0.6mm as a diameter of the stainless steel line was optimum. The apatite cement with connected open pore was implanted in the tibia of the rabbit, and the histological examination is carried out. As the result, in the interface between cement and soft tissue cement was surrounded by thin fibrous tissue with a slight inflammatory response and few foreign body giant cells were observed. There was no soft tissue in the interface with the bone, the new bone invaded inside the connected open pore and bone marrow was formed in the part These results showed that the surface area increased by the open pore formation, and the interface with the bone increased, then apatite cement with the connected open pore apatite cement quickly replaces the bone. Less