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Establisment of differentiation method from induced pluripotent stem(iPS) cells to osteoblasts via mesenchymal stem cells

Establisment of differentiation method from induced pluripotent stem(iPS) cells to osteoblasts via mesenchymal stem cells
诱导多能干细胞(iPS)经间充质干细胞向成骨细胞分化方法的建立
批准号：
22659370
负责人：
MIYAMOTO Youji
金额：
$2.11万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659370/
关键词：
iPS細胞骨再生医療間葉系幹細胞ハイドロキシアパタイト

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英文摘要
The aim of this study is to establish a method to differentiate iPS cells into mesenchymal stem cells, followed by to differentiate mesenchymal stem cells into osteoblasts, in order to efficiently differentiate from iPS cells into osteoblasts.The expressions of the markers of mesenchymal stem cells, were enhanced by addition of TGF-βand retinoic acid. Then, we examined the differentiation of the mesenchymal stem cells into osteoblasts by addition of bone induced medium. The expressions of the differentiation markers of osteoblasts were enhanced. In addition, it was revealed that the expression of these differentiation markers of osteoblasts was also increased when the mesenchymal stem cells were cultured on bioceramics, such as hydroxyapatite. Therefore, it was demonstrated that the iPS cells can differentiate into osteoblasts via the mesenchymal stem cells.
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