NanoMslide: plasmon-enhanced ptychographic phase microscopy

本提案旨在结合超材料和定量相位成像的最新进展来探测细胞和组织的近表面折射率特性。与传统的相对比显微镜相比，所提出的技术在灵敏度方面提供了数量级的改进，并将用于为疾病的分子基础提供新的见解。该项目将产生一种无染色、无标签、组织表征的新方法，这将有利于生物成像领域的各种应用，并有助于将纳米技术平台发展成为澳大利亚长期、可持续的业务。

This proposal aims to combine recent advances in metamaterials and quantitative phase imaging to probe the near-surface refractive index properties of cells and tissues. The proposed technique delivers orders of magnitude improvement in terms of sensitivity over conventional phase contrast microscopy and will be used to provide new insights into the molecular basis for disease. This project will result in a new approach to stain-free, label free, tissue characterisation that will benefit a diverse range of applications in biological imaging and aid in the development of this nanotechnology platform into a long-term, sustainable business for Australia.