Re-purposing shelved 'antibiotics' in the search for new herbicides

该项目旨在确定抑制氨基酸生物合成途径的靶向特异性除草剂化合物，以解决除草剂抗性问题。该项目希望通过利用细菌和植物酶在这些途径中的相似性来重新利用失败的“抗生素”，从而验证一种新的除草剂发现策略。预期的结果包括我们对新除草剂靶点的结构，功能和抑制的知识的进展，以及具有除草活性的化合物的鉴定。这应该为提高澳大利亚作物的数量和质量以确保我们的粮食安全的长期利益奠定基础。

This project aims to identify target-specific herbicidal compounds that inhibit amino acid biosynthesis pathways to tackle herbicide resistance. This project expects to validate a novel herbicide discovery strategy by exploiting the similarity between bacterial and plant enzymes in these pathways to re-purpose failed 'antibiotics'. Expected outcomes include advances in our knowledge of the structure, function and inhibition of novel herbicide targets, and the identification of compounds with herbicidal activity. This should lay the foundations for long-term benefits related to improving the quantity and quality of Australia’s crops to ensure our food security.