ICTOGENESIS AND EPILEPTOGENESIS IN EL MICE

在EL小鼠中，胚胎发生在大约10周大时建立，而癫痫发生将通过在发育过程中反复癫痫发作的经验来建立。提示“神经可塑性异常”可能在致痫和致痫的形成过程中起重要作用，有望成为癫痫药物治疗的新靶点。据报道，某些亚型的一氧化氮化物合成酶(nNOS和eNOS)都是建立长时程增强(LTP)现象所必需的。LTP和异常的神经可塑性将在脑生理功能的建立和癫痫障碍的发病机制中发挥关键作用。为探讨神经可塑性异常在EL小鼠脑致痫和致痫中的作用，采用生化和分子生物学方法对致痫突变体进行了分析。

In EL mice, ictogenesis has been established at around 10 weeks of age, whereas epileptogenesis will be established through experience of repetitive seizures during development. It is suggested that an "abnormal neural plasticity" may play a crucud role in the establishment of Ictogenesis and epileptogenesis, and therefore, can be a potential target for the development of a new pharmacotherapy to the epilepsy. It is reported that some isoforms of nitric oride synthetases (nNOS and eNOS) are both necessary for the establishment of long-term potentiation (LTP) phenomena. LTP and Abnormal neural plasticity will play the key roles in the establishment of physiological brain function and pathogenesis of epileptic disorder. To investigate the role of abnormal neural plasticity in the iictogenesis and epileptogenesis in EL mice brain, epileptic mutant were analized by biochemical and moleclar biological methods.