Epidemiological research on the etiology of Multiple Risk Factor Syndrome

我们在1997年对大约7，000名男性工人进行了队列研究。在这项研究中，我们研究了肥胖的作用，最有可能躺在上游的胰岛素抵抗的发生多危险因素综合征最近被称为代谢综合征（MS）。我们获得了肥胖可能导致胰岛素抵抗综合征和青春期体重变异可能导致胰岛素抵抗和MS的新认识。此外，我们发现MS的每种成分（肥胖、高血压、高甘油三酯血症、高LDL胆固醇血症、低HDL胆固醇血症、高胰岛素血症，高尿酸血症）与定义为C-反应蛋白升高的系统性低度炎症相关，CRP随着共存MS组分数量的增加而增加。根据这些结果，我们推测了发生心血管疾病的级联反应：肥胖→胰岛素抵抗→ MS的非肥胖成分→动脉粥样硬化→全身性低度炎症→进展性动脉粥样硬化→心血管事件。本研究将进一步阐明高瘦素血症、瘦素抵抗在MS发病中的作用。

We conducted the cohort study of about 7,000 male workers in 1997. In this study, we examined the role of obesity most likely lying in the upstream of insulin resistance in the genesis of Multiple risk factor syndrome recently called as Metabolic syndrome (MS). We obtained the new knowledge that obesity probably caused insulin resistance syndrome and that weight variability from adolescence probably caused insulin resistance and MS. Furthermore, we found that t each component of MS (obesity, hypertension, hypertrigriceridemia, hyper-LDL cholesterolemia, hypo-HDL cholesterolemia, hyperinsulinemia, hyperuricemia) was associated with the systemic low-grade inflammation defined as elevated C-reactive protein and that CRP increased as the number of coexisting MS components increased. From these results, we speculated the cascade of events arriving at cardiovascular disease as follows : obesity→insulin resistance→components of MS other than obesity→Atherosclerosis→systemic low-grade inflammation→progression atherosclerosis→cardiovascular event.In the view of our results, obesity plays an important role in the etiology of MS. In recent years, leptin attracts attention as hormone related to obesity. Our future research is to elucidate the role of hyperleptinemia, leptin resistance in the etiology of MS.