Association of plasma remnant-like particle cholesterol with insulin resistance in a Japanese general population

残脂蛋白含有乳糜粒和极低密度脂蛋白(VLDL)。胰岛素抵抗的特征是血脂异常。因此，残余脂蛋白胆固醇的升高与胰岛素抵抗综合征有关。因此，我们在一个饮食习惯不同、冠状动脉疾病发病率低于西方国家的日本农业社区调查了肾样脂蛋白颗粒(RLP)胆固醇与胰岛素抵抗的关系。1999年共有1,492名受试者接受健康检查，其中获得了1,465名受试者的空腹RLP-c水平数据(591名男性和874名女性；平均年龄为62.7岁)。接受降脂药物、口服降糖药或胰岛素注射的受试者被排除在这项分析之外。在1305名受试者中获得了完整的数据集。我们还测量了体重指数、腰臀比、收缩压和舒张压…高密度脂蛋白胆固醇、甘油三酯、葡萄糖、胰岛素、糖化血红蛋白(HbAIC)和尿酸。我们使用由空腹血糖和胰岛素值计算的HOMA指数作为胰岛素抵抗的指数。腰臀比和HOMA指数被分为五分位数的递增数值。糖化血红蛋白水平分为4组(<4.9%、5.0%~5.4%、5.5%~5.9%、6.0%以上)。RLP-c平均值男性为3.52 mg/dl，女性为3.46 mg/dl。通过协方差分析，调整了年龄、性别和降压药物作为协变量后，除血压外的其他参数与RLP-c显著相关(p&lt；0.01)。在调整了年龄、性别和抗高血压药物后，糖化血红蛋白、腰臀比和HOMA指数组的rlp-c水平显示出明显的剂量-反应关系(p&lt；0.001)。这是流行病学研究首次证明RLP-c与胰岛素抵抗综合征显著相关。较少

Remnant lipoprotein contains chylomicron and very low density lipoprotein (VLDL). Insulin resistance is characterized by dyslipidemia. Thus, it is suggested that increases of remnant lipoprotein cholesterol are associated with insulin resistance syndrome. Therefore, we investigated an association of renmant-like lipoprotein particle (RLP) cholesterol with insulin resistance in a Japanese farming community where the dietary habit is different and the incidence of coronary artery disease is lower compared to those of western countries. A total of 1,492 subjects received a health examination in 1999.Of these, data for fasting RLP-c levels of 1,465 subjects (591 males and 874 females ; mean age, 62.7 years) were obtained. Subjects under medication with lipid lowering drugs, oral hypoglycemic agent or insulin injection were eliminated from this analysis. A complete data set was available in 1,305 subjects. We also measured body mass index, waist-hip ratio, systolic and diastolic blood press … More ure, HDL-cholesterol, triglycerides, glucose, insulin, glycosylated hemoglobin A_<1c> (HbAic), and uric acid. We used HOMA index, which was calculated from fasting glucose and insulin values, as an index for insulin resistance. Waist-hip ratio and HOMA index were divided into quintiles of the increasing values. HbA_<1c> levels were divided into four groups (less than 4.9 %, 5.0-5.4%, 5.5-5.9 %, and more than 6.0 %). The mean RLP-c values were 3.52 mg/dl in males and 3.46 mg/dI in females. The parameters except for blood pressure were significantly (p<O.O01) associated with RLP-c by the use of analysis of covariance, adjusted for age, sex, and antihypertensive medication as covariates. RLP-c levels by the groups of HbAic, waist-hip ratio, and HOMA index showed clear dose response relationships (p<0.001) after adjustments for age, sex, and antihypertensive medication. This is the first demonstration that RLP-c was significantly related to insulin resistance syndrome in an epidemiological study. Less