Vascular remodeling in Kawasaki disease

目的：通过随访冠状动脉造影术观察KD患者冠状动脉退行性变和正常者的远期结果，并评价冠状动脉内灌注ACh和ISDN对血管功能的影响。KD后远期消退的冠状动脉瘤存在血管壁形态异常和血管功能障碍。这些患者应该得到咨询，以避免动脉粥样硬化的潜在危险因素，并需要长期随访，直到成年。我们比较了静脉注射免疫球蛋白(IVIG)和类固醇冲击疗法在IVIG抵抗的川崎病患者中的有效性和安全性。激素冲击治疗时可观察到短暂的冠状动脉扩张，因此应对接受激素冲击治疗的患者进行仔细的超声心动图检查，以便及早发现冠状动脉异常。本研究采用定量冠状动脉造影术(QCA)和血管内超声(IVUS)评价川崎病(KD)导管介入治疗的序贯随访结果。川崎病患者冠状动脉狭窄病变的介入治疗在短期内显示出显著的疗效。导管介入治疗KD的长期疗效尚不清楚。为了证实这一发现，应该需要更多的长期跟踪研究。为了验证这一发现，应该需要更多的液化天然气长期随访研究。本指南是小组成员根据日本和海外报道的诊断和治疗评估信息，就如何有效和适当地对川崎病冠状动脉梗阻性疾病进行导管介入治疗的最新意见摘要。

To investigate the long-term consequences of regressed and normal coronary artery after KD using follow-up coronary angiography and to evaluate the vascular function of those using intracoronary infusion of ACh and of ISDN. The long-term regressed coronary aneurysms after KD had abnormal vascular wall morphology and vascular dysfunction. These patients should be counseled to avoid potential risk factors for atherosclerosis and long-term follow-up is needed into adulthood. We compared the efficacy and safety of additional intravenous immune globulin (IVIG) therapy With steroid pulse therapy in IVIG-resistant Kawasaki disease patients. ransient dilatation of the coronary artery is observed during steroid pulse therapy, so that careful echocardiographic examination should be performed for those patients receiving steroid pulse therapy for the ake of early detection of coronary artery abnormalities. This study was undertaken to assess the sequential follow-up results of catheter intervention in Kawasaki disease (KD) using quantitative coronary angiography(QCA) and intravascular ultrasound (IVUS) imaging. The catheter intervention for coronary artery stenotic lesions in KD demonstrated significant therapeuticc effects in the short, term. The long-term efficacy of catheter intervention for KD is unclear. To verify this finding, more long-term follow-up studies should be needed. To verify this finding, more lng-term follow-up studies should be needed. This guideline is an update summary of the group members opinions on how to effectively and appropriately perform catheter interventional treatment in coronary obstructive disease in Kawasaki disease on the basis of the information regarding evaluation of the diagnosis and the therapy reported in Japan and overseas.