Epidemiological study on the relationship between ischemic heart disease and infection of Chlamydia pneumoniae.

本病例对照研究的目的是通过检测IgG和IgA抗体的存在，探讨缺血性心脏病（IHD）与肺炎衣原体（C.pneumoniae）感染之间的关系。纳入受试者625例。所有病例均经冠脉造影证实为冠状动脉狭窄，采用igg和iga特异性酶试剂盒（Hitachikasei, Tokyo）测定肺炎原体血清阳性。采用logistic回归模型分析急性冠脉综合征（ACS）患者与对照组之间肺炎原体血清阳性的关系。数据采用SPSS公司（Statistical Product and Service Solution, Chicago， IL）进行分析。概率值小于0.05被认为显著。424例男性患者中冠状动脉狭窄333例。无狭窄，正常范围内（WNL） 91例。对照组无IHD病史，静息心电图正常47例。肺炎原体igg血清阳性率：狭窄组为46.9%，WNL组为51.9%，ACS组为57.4%。关于肺炎原体iga血清阳性率，狭窄组62.5%，WNL组60.2%，ACS组53.2%。肺炎原体血清阳性差异无统计学意义。观察31例ACS与肺炎原体感染的关系。所有ACS均为发病病例。在门诊患者中随机选择62例作为对照。肺炎原体血清阳性差异无统计学意义。

The purpose of this case-control study, carried out by examining for the presence of IgG and IgA antibodies, was to investigate the relationship between ischemic heart disease (IHD) and Chlamydia pneumoniae (C.pneumoniae) infection. Enrolled subjects were 625 cases. All cases were angiographically confirmed stenosis of coronary artery C.pneumoniae seropositivity was determined with an IgG-and an IgA-specific enzyme kit (Hitachikasei, Tokyo). The logistic regression model was applied to analyze a relationship between acute coronary syndromes (ACS) and controls in regard to C.pneumoniae seropositivity The data were analyzed with the Statistical Product and Service Solution (SPSS Inc, Chicago, IL). Probability values less than 0.05 were considered significant.Of 424 male patients, patients with stenosis of coronary arteries were 333. Non-stenosis cases with the result of within normal limit (WNL)' were 91cases. Controls without a history of IHD and with a resting ECG is normal were 47 cases. As regards IgG-seropositive rates of C.pneumoniae, 46.9% in a stenosis group, 51.9% in a WNL group and 57.4% in an ACS group. With respect to IgA-seropositive rates of C.pneumoniae, 62.5% in a stenosis group, 60.2% in a WNL group and 53.2% in an ACS group. No statistical significance was recognized on seropositivity of C.pneumoniae.'A relationship between ACS (31 cases) and C.pneumoniae infection was observed. All ACS were incidence cases. Controls (62 cases) were at random selected in outpatients. No statistical significance was -recognized on seropositivity of C.pneumoniae.