A study on regulatory mechanism for gene expression in tongue and masseter muscles by adenovirus vector

众所周知，肽生长因子在骨骼肌形成中起着重要作用。舌横纹肌具有其他骨骼肌（如四肢和躯干肌肉）所没有的一些独特特征，这意味着生长因子在舌肌发生中的作用不同于四肢和躯干的肌肉发生。因此，我们研究了胰岛素样生长因子（IGFs）、肝细胞生长因子（HGF）和转化生长因子α(TGFα)在小鼠舌肌发生中的作用。igf - 1促进舌成肌细胞分化。HGF促进舌成肌细胞的迁移和增殖，抑制舌成肌细胞的分化。tgf - α促进舌成肌细胞分化。igf - 1和HGF在舌肌生成中的作用似乎与肢体肌生成和培养的肌生成细胞系（如C2和L6）中的作用几乎相同；另一方面，tgf - α的作用似乎与它们不同。目前尚不清楚tgf - α作用的差异是否归因于或与舌横纹肌的独特特征有关。

It is well known that peptide growth factors play important roles in skeletal myogenesis. It is also known that tongue striated muscles have several unique characteristics not found in other skeletal muscles, such as limb and trunk muscles, implying that roles of growth factors in tongue myogenesis differ from those in the myogenesis of limb and trunk. Thus, we have studied the roles of insulin-like growth factors (IGFs), hepatocyte growth factor (HGF), and transformig growth factor α(TGFα) in mouse tongue myogenesis. IGF-I promotes the differentiation of tongue myoblasts. HGF promotes the migration and proliferation of tongue myogenic cells, but it inhibits the differentiation of tongue myoblasts. TGFα promotes the differentiation of tongue myoblasts. The roles of IGF-I and HGF in tongue myogenesis seem to be almost identical to those in the myogenesis of limb and cultured myogenic cell lines, such as C2 and L6 ; on the other hand, the role of TGFα seems to differ from them. It is still unknown if the difference in the role of TGFα is ascribed or related to the unique characteristics of tongue striated muscles.