Bioactive natural products which support Okinawan traditional cultures for food stuffs and medicines

对冲绳资源植物的成分进行了研究。分离得到了几种黄酮醇苷类化合物，并通过光谱分析对其结构进行了鉴定。从肉豆蔻中分离到几种大葛缕梅苷，并分离到相当数量的熊果苷。熊果苷含量高，有望成为熊果苷的良好来源，用于化妆品。从针叶松中分离到具有外亚甲基官能团的四萜苷。众所周知，外亚甲基具有杀菌活性，当人们吃生鱼时，嫩叶被用作添加剂。有趣的是，它的实际用途和其成分的生物活性表现出很好的一致性。用大鼠白血病细胞RBL-2H3检测抗组胺活性。考虑到在一次任务中可以收集到5到6株植物，应该是随机筛选粗提物的好时机。马鞭草科和大戟科植物显示出良好的活性和有待研究的活性化合物。

Continuing works on Okinawan resource plants, constituents in Glochidion zeylanicum were investigated. Several flavonol glycosides were isolated and their structures were elucidated by spectroscopic analysis. From Myrisine seguinii, several megastigmane glucosidses were isolated along with a considerable amount of arbutin. Content of arbutin is fairy high and the plant expected to be a good source of arbutin, used for cosmetics.From Cresipidia lanceolatum, sequiterpene glucosides, which have an exo methylene functional group, were isolated. The exo methylene is known to have bactericidal activity and young leaves are used as an additive, when people eat raw fish. It is interesting that its actual usage and biological activity of its constituents showed good coincidence.Using Rat leukemia cells, RBL-2H3, anti-histaminic activity was assayed. Considering that, five or six plants were collectable in one mission, it must be good time for random screening of crude extracts. Plants belonging to Verbenaceae and Euphorbiaceae showed promising activity and awaiting to be investigated active compounds.