REGULATION OF RYANODINE RECEPTOR CALCIUM CHANNELS BY THE CALCIUM BINDING PROTEIN CALSEQUESTRIN

该项目旨在研究骨骼肌中两种蛋白质之间的功能相互作用，这两种蛋白质对所有脊椎动物物种的Ca2+调节以及收缩，呼吸和运动至关重要。 一种蛋白质，ryanodine受体，从肌肉细胞中释放钙。 另一种蛋白质，钙螯合蛋白，结合并螯合钙离子。 我们最近发现，这些蛋白质也相互结合，并且钙螯合蛋白通过ryanodine受体离子通道调节Ca 2+从储存中释放。 这种调节可能在压力或疲劳期间保存储存的钙方面很重要。

The project is to examine the functional interaction between two proteins in skeletal muscle that are essential for Ca2+ regulation and hence contraction, respiration and movement in all vertebrate species. One protein, the ryanodine receptor, releases calcium from stores inside the muscle cell. The other protein, calsequestrin, binds and sequesters calcium ions. We have recently discovered that the proteins also bind to each other and that calsequestrin regulates Ca2+ release from the stores through the ryanodine receptor ion channel. This regulation is likely to be important in conserving store calcium during stress or fatigue.