Structural Determinants of an Intracellular Calcium Store.

细胞内钙储存的结构决定因素。

• 批准号: DP0773683
• 负责人: Prof Angela Dulhunty
• 金额: $ 18.25万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773683
• 关键词: Structural; Determinants; Intracellular; Calcium; Store.

Understanding the molecular interactions between key proteins in calcium signalling in muscle and the heart will allow calcium signalling to be used as a platform for a variety of purposes. These include reducing the debilitating effects of changes in calcium signalling and muscle performance in aging and in genetically- or drug-induced disorders. The project will have benefits for Australian biotechnology since it will facilitate the design of novel compounds for treating muscle disorders in animals and humans, for improving meat quality and for use as insecticides. The project will facilitate graduate and undergraduate training in basic science with exposure to biotechnology, through our commercial partner Biotron.

了解肌肉和心脏中钙信号关键蛋白之间的分子相互作用将使钙信号成为一个平台，用于各种目的。这些措施包括减少衰老和遗传或药物引起的疾病中钙信号和肌肉性能变化的衰弱效应。该项目将有利于澳大利亚生物技术，因为它将促进设计新的化合物，用于治疗动物和人类的肌肉疾病，改善肉类质量，并用作杀虫剂。该项目将通过我们的商业合作伙伴Biotron，促进基础科学方面的研究生和本科生培训，并接触生物技术。