High Pressure and Fluorous Approaches to Fostriecin Libraries: New Therapeutic Opportunities.

天然产物Fostriecin通过一种新的作用机制显示出相当广泛的抗癌活性。然而，这种活性由于其相当不稳定，太不稳定而不能用作治疗剂而受到影响。使用最先进的方法，我们将迅速建立更稳定和更具生物活性的Fostriecin类似物的库，并检查它们作为抗癌药物的潜力。该项目为澳大利亚提供了一个机会，使其能够在开发迄今为止未被预见的治疗剂方面取得重大的创新领先地位。

The natural product, Fostriecin, displays considerable broad-spectrum anti-cancer activity, acting via a novel mechanism. However, this activity is tempered by its considerable instability, being too unstable to be used as a therapeutic agent. Using state-of-the-art approaches we will, rapidly generate libraries of more stable and biologically active fostriecin analogues and examine their potential to be used anti-cancer agents. This project represents an opportunity for Australia to take a significant, innovative lead in the development of hitherto unforseen therapeutic agents.