Molecular status of RBICCI in various disea,and trial for the clinical application

为了阐明RB1CC1(RB1诱导的卷曲线圈1)在人类多种疾病中的分子状态，我们启动了这一项目，并试图将分子通路应用于临床医学。结果，我们发现RB1CC1缺乏通过TSC1的不平衡导致mTOR信号抑制，诱导神经元萎缩，进而参与阿尔茨海默病的发病机制。最近，我们的研究还表明，RB1CC1是连接RB1和P53通路的一种新的介质，联合评估RB1CC1和P53的状态将为乳腺癌患者提供一种常规、准确的预后检测方法。

To clarify the molecular status of RB1CC1 (RB1-inducible coiled-coil 1) in various human diseases, we started this project, and have intended to apply the molecular pathways into clinical medicine.In a consequence, we identified that RB1CC1 insufficiency resulted in mTOR signaling repression through unbalanced TSC1 abundance, induced neuronal atrophy, and then were involved in the pathogenesis of Alzheimer's disease.More recently, our study also has demonstrated that RB1CC1 is a novel mediator connecting the RB1 and p53 pathways, and that the combined evaluation of RB1CC1 and p53 status will provide a routine, accurate prognostic test for patients with breast cancer.