Development of small diameter artificial blood vessel for remodeling of elastomeric-artery

本研究的目的是开发一种新型的小直径人造血管，使用弹性蛋白基质治疗血管疾病。2004年（第一年），制作了细胞培养皿和动态细胞培养用弹性片。2005年（第二年），研究了这些材料与血管壁细胞的粘附性能。2006年（最后一年）研究了弹性蛋白基质上的平滑肌细胞的分化特性，对弹性片上的平滑肌细胞、内分泌细胞和成纤维细胞进行了评价，结果显示弹性蛋白材料促进平滑肌细胞的分化和抑制增殖是重要的信息。在本研究中，我们认为弹性蛋白基质是在动态细胞培养条件下进行动脉重塑的合适材料。

The aims of this study are the development of a novel small diameter artificial blood vessel using elastin matrix for treatment of vessel disease. In 2004 (first year), the cell cultured dish and elastic-sheet for the dynamic cell culture were prepared. And in 2005 (second year), the adhesion properties was researched as the reactions of blood wall-cells for these materials. In 2006 (final year), the differentiation property of smooth muscle cells on the elastin-matrix was researched.The smooth muscle cells, endocrinal cells and fibroblast cells were evaluated on the elastic-sheets, in results, the important information was taken as the acceleration of differentiation of smooth muscle cells and the inhibition of proliferation by elastin materials. In this study, we concluded that elastin matrix was the suitable material for remodeling of elastomeric-artery under dynamic cell culture conditions.