Dose the mast cell -dependent activation of the secretion of stress hormone potentially help to save the life of an allergic individual

在结节和正中隆起部可见大量肥大细胞。当这些大脑肥大细胞被免疫球蛋白E通过脑室内或静脉途径被动致敏时，随后的抗原攻击(无论是通过中心途径还是外周途径)引发的肾上腺皮质醇和肾上腺素分泌显著增加。化合物48/80(C48/80)是一种肥大细胞分泌剂，侧脑室给药时，不仅能增加肾上腺的皮质醇和肾上腺素的分泌，还能增加血浆肾素活性和血浆ADH水平。切除双侧隔下内脏神经可完全阻止IgE或C48/80引起的PRA和肾上腺素的增加，但不能阻止皮质醇和ADH的增加。酮替芬(肥大细胞稳定剂，实验前口服1wk)显著降低了Ig E和C48/80诱导的体液f…的升高。更多的演员。脑室注射抗促肾上腺皮质激素释放因子抗体或组胺H^1阻滞剂可减轻肥大细胞依赖性激素和肾素的增加。相反，脑室注射组胺H^2受体阻滞剂可增强肥大细胞依赖性这些物质的增加。这些数据表明，在狗中，大脑肥大细胞的脱颗粒通过中枢释放组胺和下丘脑促肾上腺皮质激素释放因子来激发垂体-肾上腺和/或交感-肾和肾上腺髓质反应。根据这些数据，我们认为大脑肥大细胞可能作为过敏原传感器。此外，我们认为，依赖于大脑肥大细胞的肾上腺皮质分泌和血管活性物质的增加可能有助于挽救个体的生命，因为它不仅可以改善高免疫反应的影响，还可以改善心血管和呼吸功能障碍，否则会在I型过敏爆发期间发生。较少

A large number of mast cells were found in the pars tuberalis and median eminence. When these brain mast cells were passively sensitized with immunoglobulin E via either the intracerebroventricular or intravenous route, there were marked increases in the adrenal cortisol and epinephrine secretion elicited by a subsequent antigenic challenge (whether this was delivered via the central or peripheral route). Compound48/80 (C48/80), a mast cell secretagogue, increased not only cortisol and epinephrine secretion from the adrenal glands but also increased plasma renin activity and plasma level of ADH when administered intracerebroventricularly. Resection of the bilateral splanchnic nerves below the diaphragm completely prevents the IgE-or C48/80-induced increases in PRA and epinephrine, but not increases in cortisol and ADH. Ketotifen (mast cells-stabilizing drug; given orally for 1 wk before the experiment)significantly reduced both of the IgE- and C48/80-induced increases in such humoral f … More actors. Pretreatment with anti-corticotropin-releasing factor antibodies or a histamine H^1-blocker attenuated the mast cell-dependent increases in such hormones and renin when given intracerebroventricularly. In contrast, pretreatment with a histamine H^2-blocker given intracerebroventricularly potentiated the mast celldependent increases in these substances. These data show that in the dog, degranulation of brain mast cells evokes the pituitary-adrenal and/or sympathetic-renal & adrenomedullary responses via centrally released histamine and hypothalamic corticotropin-releasing factor. On the basis of these data, we suggest that brain mast cells may act as an allergen sensor. Furthermore, we suggest that the brain mast cells-dependent increases in adrenocortical secretion and vasoactive substances could potentially help to save the life of an individual by ameliorating the effects of the not only hyper-immune reactions but also cardiovascular and respiratory dysfunction that would otherwise occur during an outbreak of type-I allergy. Less