New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation

对映体的表征可以评估潜在有害成分的药物纯度，保护消费者免受精油和天然材料掺假，以及研究生化/环境系统中的化学相互作用。对映体分离的色谱技术（气相色谱，高效液相色谱和CE）是可用的，但是限制阻止了完整样品混合物的多组分表征。关键的选择包括：选择对所有对映体都有不同作用的手性选择器；将选择器纳入高效色谱系统；适用于样品中的所有目标化合物。我们将合成新的手性选择器，并将其整合到新的分离柱中，将超高分辨率二维GCxGC应用于挥发性化学样品的广谱手性分析。

Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.