Molecular characterization of marsupial genome organization, function and evolution

我将开始对澳大利亚有袋动物（tammar wallaby）的基因组进行连贯的调查，利用新资源，新技术和在分子水平上大规模调查基因组的巨大增长能力。我将分离和表征Y染色体基因丰富区域的大插入（BAC）克隆，X染色体的古老，添加和控制区域，以及常染色体印迹区域。与人类和小鼠基因组的同源区域的比较将识别和表征新的哺乳动物基因和控制信号，解开复杂的调控系统，并发现哺乳动物基因和哺乳动物基因组是如何进化的。

I will initiate a coherent investigation of the genome of an Australian marsupial (the tammar wallaby), exploiting new resources, new techniques and the hugely increased capacity for large-scale investigations of genomes at the molecular level. I will isolate and characterize large-insert (BAC) clones of the gene-rich region of the Y chromosome, ancient, added and controlling regions of the X chromosome, and autosomal imprinted regions. Comparisons with the homologous regions of the human and mouse genomes will identify and characterize new mammalian genes and control signals, untangle complex regulatory systems, and discover how mammalian genes, and the mammalian genome, evolved.