Does low bone mass predict atherosclerotic cardiovascular disease? ; 10-year follow-up of a large population-based randomized sampled survey

本研究旨在调查低骨量是否预示动脉粥样硬化增加。2006年，我们对1 040名妇女进行了为期10年的跟踪调查（跟踪率：68.6%）。我们分析了2006年609名年龄在50岁或以上的女性，测量了她们的颈动脉分叉处内膜中层厚度（BIF-IMT）。有脊柱T评分的受试者的校正BIF-IMT值？绝经后10年以下的女性（YSM）椎体骨折的平均直径分别为1.19mm、1.34mm、1.57mm;绝经后10年以下的女性（YSM）椎体骨折的平均直径分别为1.30mm、1.32mm、1.53mm; 10例基线时无高血压史（线性趋势均为p<0.05）。这些关联与年龄、BMI、总胆固醇、吸烟和饮酒习惯、糖尿病史和基线时的高血压（对于小于10岁的YSM组）无关。在2006年随访的613名50岁或50岁以上的女性中，有21例心血管事件。对绝经前、围绝经期、YSM<10、YSM？10，基线时腰椎骨状态与心血管事件之间无显著性差异。在调整基线时的年龄、体重、身高、总胆固醇与HDL胆固醇的比值、高血压和糖尿病史以及吸烟习惯后，YSM<10的患者中骨质减少与心血管事件的比值比接近36.76（p=0.073）。在839名受试者中进行了类似的分析，包括2006年的非参与调查，随后进行了关于心血管事件信息的问卷调查，两者均无显著相关性，骨质疏松症包括普遍的椎骨骨折可能预测绝经后妇女未来10年的颈动脉粥样硬化。

This study was conducted to investigate whether low bone mass predicts increased atherosclerosis. In 2006, we conducted a 10-year follow-up survey of 1,040 women (follow-up rate: 68.6%). We analyzed 609 women aged 50 years or older in 2006 whose intima-media thickness of carotid bifurcation (BIF-IMT) was measured. Adjusted BIF-IMT values of subjects with spine T-score ? -1, between -2.5 and -1, and <-2.5 or prevalent vertebral fracture were 1.19mm, 1.34mm, 1.57mm, respectively, in women with less than 10 years since menopause (YSM), 1.30mm, 1.32mm, 1.53mm, in women with YSM ?10 without a history of hypertension at baseline (both with p<0.05 for liner trend). Those associations were independent of age, BMI, total cholesterol, smoking and drinking habits, history of diabetes mellitus, and hypertension (for the less than 10 YSM group) at baseline.In 2007, we set up the database with data of cardiovascular event. There was 21 cardiovascular events among 613 women aged 50 years or older followed in 2006. With multivariate analyses among premenopause, perimenopause, YSM<10, YSM ? 10, there was neither significance between lumbar bone status at baseline and cardiovascular event. Odds ratio of osteopenia for cardiovascular event was near significance of 36.76 (p=0.073) in YSM<10, after adjusting for age, weight, height, ratio of total cholesterol to HDL cholesterol, history of hypertension and diabetes mellitus, and smoking habits, at baseline. With similar analyses among 839 subjects including nonparticipation in 2006 followed by a questionnaire about information regarding cardiovascular event, there was neither significant relationship.Osteoporosis including prevalent vertebral fracture may predict carotid atherosclerosis in the next 10 years in postmenopausal women.