Design and characterisation of a polysaccharide-based biomaterial for tissue adhesion

本研究旨在设计一种新型的生物粘附材料，并研究其对组织粘附的作用机制。 目前的缝合技术除了简单的修复外还不足以进行任何手术，而目前可用的外科胶水所提供的替代方案最多只能是扩大手术范围。将强粘性生物材料与加速伤口愈合的因素相结合，将产生一种新型材料技术，通过将伤口闭合与密封相结合，解决了手术中未满足的需求。 这些调查的主要结果将是： 1.组织-生物材料粘附机理理论的进展 2.了解激光二极管的可见光对细胞和分离组织的影响 3.基于壳聚糖多糖的生物相容性可见光激活的用于组织修复的粘合膜

This proposal aims to design a new bio-adhesive material and study the mechanisms of action for tissue adhesion. Current suture technology is inadequate for anything but simple repairs and the alternative offered by surgical glues available today is at most augmentation of suturing. Combination of a strong adhesive biomaterial with factors for accelerating wound healing will generate a novel material technology that, by uniting wound closure with sealing, addresses an unmet need in surgery. The primary outcomes of these investigations will be: 1. advancement of knowledge in theories of tissue-biomaterial adhesion mechanisms 2. knowledge of effects of visible light from laser diodes on cells and isolated tissue 3. a biocompatible, visible light activated adhesive film for tissue repair based on chitosan polysaccharides