ANALYSIS OF IMMUNOLOGICAL TARGET MOLECULES FOR MOLECULAR PREVENTION OF ASBESTOS-RELATED TUMOR FORMATIONIN CASES WHO EXPOSED ASBESTOS

众所周知，石棉暴露不仅会导致在工作环境中接触石棉的人患上石棉相关疾病，如石棉肺、肺癌和恶性间皮瘤（MM），而且也会导致居住在接触石棉的工厂附近的居民患上石棉相关疾病。自2005年夏天以来，这些事实在日本已经成为一个巨大的医疗和社会问题。本文就石棉和二氧化硅对人体免疫系统的影响作一综述，介绍了多发性骨髓瘤患者的免疫学变化及其实验检测。例如，在MM患者中发现，在CD4+外周T细胞中存在BCL-2的过度表达、高血浆浓度的白细胞介素（L）-10和转化生长因子（TGF）-β以及外周CD3 + T细胞中T细胞受体（TCR）-V β的多重过度激活。我们还建立了一个实验性长期暴露的T细胞模型。分析石棉的免疫效应有助于了解石棉的生物学效应。免疫分子研究的最新进展导致了对石棉免疫效应的详细分析。石棉影响免疫活性细胞，这些影响可能与石棉暴露患者并发症（如恶性肿瘤）的病理生理发展有关。此外，免疫学分析可能导致发现用于改变疾病病理生理方面的新临床工具，例如使用细胞介导疗法、各种细胞因子和分子靶向疗法调节肿瘤免疫。随着石棉相关恶性肿瘤发病率的增加，以及自2005年夏季以来日本对此类恶性肿瘤造成的医疗和社会问题的日益关注，应重新集中努力，为这些疾病找到治疗方法，以消除全国对这些恶性肿瘤的担忧。

IT IS COMMON KNOWLEDGE THAT ASBESTOS EXPOSURE CAUSES ASBESTOS-RELATED DISEASES SUCH AS ASBESTOSIS, LUNG CANCER AND MALIGNANT MESOTHELIOMA (MM) NOT ONLY IN PEOPLE WHO HAVE HANDLED ASBESTOS IN THE WORK ENVIRONMENT, BUT ALSO IN RESIDENTS LIVING NEAR FACTORIES THAT HANDLE ASBESTOS. THESE FACTS HAVE BEEN AN ENORMOUS MEDICAL AND SOCIAL PROBLEM IN JAPAN SINCE THE SUMMER OF 2005. WE FOCUSED ON THE IMMUNOLOGICAL EFFECTS OF ASBESTOS AND SILICA ON THE HUMAN IMMUNE SYSTEM IN THIS BRIEF REVIEW, WE PRESENT IMMUNOLOGICAL CHANGES IN PATIENTS WITH MM AND OUTLINE THEIR EXPERIMENTAL DETECTION. FOR EXAMPLE, THERE IS OVER-EXPRESSION OF BCL-2 IN CD4+ PERIPHERAL T CELLS, HIGH PLASMA CONCENTRATIONS OF INI'ERLEUKIN (L)-l0 AND TRANSFORMING GROWTH FACTOR (TGF)-β AND MULTIPLE OVER ON OF T CELL RECEPTOR (TCR)-Vβ IN PERIPHERAL CD3+ T CELLS FOUND IN MM PATIENTS. WE ALSO DETAIL AN EXPERIMENTAL LONGTERM EXPOSURE T-CELL MODEL. ANALYSIS OF THE IMMUNOLOGICAL EFFECTS OF ASBESTOS MAY HELP OUR UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF ASBESTOS. RECENT ADVANCES IN IMMUNOMOLECULAR STUDIES HAVE LED TO DETAILED ANALYSES OF THE IMMUNOLOGICAL EFFECTS OF ASBESTOS. ASBESTOS AFFECTS IMMUNOCOMPETENT CELLS AND THESE EFFECTS MAY RE ASSOCIATED WITH THE PATHOPHYSIOLOGICAL DEVELOPMENT OF COMPLICATIONS IN ASBESTOS-EXPOSED PATIENTS SUCH AS MALIGNANT TUMORS. IN ADDITION, IMMUNOLOGICAL ANALYSES MAY LEAD TO THE DISCOVERY OF NEW CLINICAL TOOLS FOR THE MODIFICATION OF PATHOPHYSIOLOGICAL ASPECTS OF DISEASES, SUCH AS THE REGULATION OF TUMOR IMMUNITY USING CELL-MEDLATED THERAPIES, VARIOUS CYTOKINES AND MOLECULE-TARGETING THERAPIES. AS THE INCIDENCE OF ASBESTOS-RELATED MALIGNANCIES INCREASES AGAINST THE GROWING CONCERN IN JAPAN SINCE THE SUMMER OF 2005 FOR MEDICAL AND SOCIAL PROBLEMS CREATED BY SUCH MALIGNANCIES, EFFORTS SHOULD RE FOCUSED ON DEVELOPING A CURE FOR THESE DISEASES IN ORDER TO ELIMINATE THE NATIONWIDE ANXIETY CONCERNING THESE MALIGNANCIES.