Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and Receptors

我们建立了一种全合成雪卡毒素的通用方法。雪卡毒素的实用全合成使我们能够将其用于跨学科研究，例如揭示电压敏感性钠通道的门控机制。建立了高灵敏度的抗CTX1B单克隆抗体和免疫分析方法，用于检测雪卡毒素的主要同系物。对以前制备的一些抗体进行了修饰，用于治疗人雪卡毒素中毒。此外，还设计合成了假雪卡毒素作为生物探针，以了解其生物学机制。另一方面，完成了极强的抗肿瘤色蛋白九元烯二炔抗生素和皮质抑素的全合成。

We have developed a general method for the total syntheses of ciguatoxins. Practical total synthesis of ciguatoxins allowed us to use them for interdisciplinary researches, such as unveiling the gating mechanism of voltage sensitive sodium channels. Highly sensitive anti-CTXlB monoclonal antibodiy and immunoassay method were developed to detect major congeners of ciguatoxin. Some of the previously prepared antibodies were modified for treating the human ciguatera poisoning. Furthermore, designed pseudo-ciguatoxins were also synthesized as bio-probes for understanding the biological mechanisms. On the other hand, total syntheses of the extremely potent antitumor chromoprotein nine-membered enediyne antibiotics and cortistatins were accomplished.