Conquest of myocardial ischemia reperfusion injury-Control of RISK pathway and antioxidant mechanism-

心肌保护对缺血再灌注损伤的保护是临床上的重要问题之一。我们研究了围手术期使用的吸入麻醉剂和循环激动剂的药物预适应和后处理效应的分子机制。因此，我们明确了再灌注损伤挽救激酶(Risk)通路参与了心肌保护作用。此外，我们还明确了内源性抗氧化机制参与了心肌细胞凋亡的控制。

Myocardial protection against the ischemia reperfusion injury is one of the clinically important problems. We examined the molecular mechanism of pharmacological preconditioning and postconditioning effects of inhalation anesthetic and circulation agonist to use for the perioperative period. As a result, we made clear that reperfusion injury salvage kinase (RISK) pathway was involved in myocardial protective effects. Also, we made clear that an endogenic antioxidant mechanism was involved in myocardial apoptosis control.