Exploration of causative or marker gene for canine cryptorchidism and application to the genetic diagnosis

在目前的研究中，根据顺序识别大麻密码学的因果基因或标记基因，雌激素受体和基因（ESR1）的一部分（70 kb区域内的9个单核苷多态性，3'终端）在小品种的密码狗中进行了实验，并与正常动物进行了比较。根据结果，在迷你Duchshunds和Chihuahuas之间发现的单一核苷酸多态性的频率没有明显的差异。然而，与正常动物不同的加密狗的多态性的频率也有被测试的数量较小的受影响狗，因此需要进一步的研究来确定在ESR1中的双边加密狗和多态性之间的关联。

In the present study, in order to identify causative gene or marker gene for canine cryptorchidism, a part (9 single nucleotide polymorphisms in 70kb region from 3'terminal) of estrogen receptor・gene (ESR1) was examined in cryptorchid dogs of small breeds and compared with normal animals. As the results, no clear differences of the frequency of the single nucleotide polymorphisms were found in Miniature Duchshunds and Chihuahuas between cryptorchid and normal dogs. However, frequencies of the polymorphisms of cryptorchid dogs differed with normal animals although the examined number of affected dogs was small, and thus further studies are required to determine the associations between bilateral cryptorchidism and the polymorphism in ESR1.