Studies on the Molecular Mechanism of Species-specific Recognition in Biological Diversity

小鼠淋巴瘤P388 D1细胞有6个热休克蛋白70（HSP 70）C端可变区的候选受体，分子大小在130 ~ 300 kDa之间，具有种属特异性。我们发现，物种特异性的多样性有助于在非致死性热休克后的小鼠LL/2肺癌的细胞表面呈递，在结合到CD 11b-，CD 11 c-，或NK1.1阳性的先天性免疫细胞，也在从nalve T细胞分化为调节性T细胞。

Murine lymphoid neoplastic P388D1 cells were found to have six receptor candidates with the molecular sizes in the range from 130 to 300kDa which discriminate species-specificity among the C-terminal variable regions of heat shock protein 70 (HSP70). We revealed that species-specific diversity contributes in the cell-surface presentation on murine LL/2 lung carcinoma upon non-lethal heat shock, in the binding to CD11b-, CD11c-, or NK1.1-positive innate immune cells, and also in the differentiation to regulatory T cells from nalve T cells.