Establishment of minimal invasive treatment system for breast cancer using real-time MRI navigation

本研究的目的是建立乳腺癌实时MRI导航微创治疗系统。我们在患者同意的情况下，在全乳切除术前对乳腺癌进行MR引导下的微波凝固治疗。我们证实了人体乳腺肿瘤消融术的安全性和可行性。患者在全身麻醉下在开放MR中设置脊柱位置。我们能够通过真实的时间MR图像观察肿瘤的位置，并在观看真实的时间监视器的情况下将消融针插入肿瘤。肿瘤消融一次（60W，60s × 3次）。此后，进行了全乳房切除术。对切除的标本进行大体和显微镜检查。切除面积约为20×30 mm，经NADH染色，切除区域内肿瘤活力消失。在皮肤中未观察到并发症。提示微波凝固治疗乳腺癌是安全可行的。我们能够确认基本信息，以便在不久的将来申请临床试验。

The aim of this study is to establish minimal invasive treatment system for breast cancer using real-time MRI navigation. We performed MR-guided microwave coagulation therapy against breast cancer before total mastectomy under patients' agreement. We confirmed the safety and feasibility of breast tumor ablation in human body. Patient was set spine position in the Open MR under general anesthesia. We were able to observe the position of tumor by real time MR image and insert ablation needle into the tumor watching real time monitor. Tumors were ablated on one session (60W, 60seconds × 3times). Thereafter total mastectomy was performed. The resected specimens were evaluated macroscopic and microscopic examination. The ablated area was confirmed as approximately 20×30 mm. The viability of tumor was disappeared in this ablated area by NADH staining. There was no complication observed in the skin. Our finding suggested the microwave coagulation therapy might be safe and feasible to treat breast cancer in the human body. We were able to confirm basic information to apply clinical trial in the near future.